Wonderful! 
I feel like the worm bot hasn’t really gotten started yet and is only scratching the surface of what’s possible. There should be much more funding from ordinary people—I think many of them don’t even know it exists. Hopefully the new feature will make it more accessible to the general public.
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Opens the door to many smaller custom projects. I’m excited to see what the community comes up with.
I actually have some interesting ideas I’ve been cooking up and this makes them possible.
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I’ll contribute once the link is up.
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I’m going to ping everybody who has commented here once the link is up.
I apologize to everybody for the link not being up sooner but this part is not in my control, and it is a completely new feature by Ora Biomedical so I don’t hold it against them that they want this done to an acceptable level before launching this beta test fundraiser feature.
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Given it’s playing with Mitocondria Complex I and especially the interests by @John_Hemming i’m contributing his same amount for this effort.
Fabio
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Has enough been raised?
Who gave the dosing amount for the test though and what is the dosing based on?
I can help contribute a bit. Perhaps they should treat more than one dose, do you know what pricing would be in that context?
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Umbrella Labs is running a 23% off Memorial day sale today. I ordered 4 bottles of the liquid IPAM for $100.80 : 180mg IPAM per 30ml bottle, so each bottle is good for 90 days at 2mg/day or 30 days at 6mg/day (the dosage range suggested in reddit threads). 2mg/day is comparable to the 0.3mg/kg suggested for mice : 0.3mg/kg x 70kg / 12 (human metabolic factor adjustment) = 1.75mg.
You could buy 2g of IPAM for about the same price today, but I prefer the simplicity of dosing with a dropper.
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I think the community is going to be able to fund this pretty much immediately when the link is out. Ora said they should have it up by around 6/1, fingers crossed it is sooner.
The dosing is based on the highest and most effective dose in rotifers, 30μg. This is what Ora suggested, and it makes sense as a starting point. It’s hard to allometrically scale between non-mammals, so picking any other amount would be a guess.
Every extra dose would likely be $100 extra, the same as any other substance in stock on MMC. I think once the IPAM has been purchased they will have a lot left over so it will go into their substance database for people to do their own tests on. If it’s successful we could do a dose escalation to see what the most effective dose is, then try some combinations with the most effective dose of IPAM.
From there, there are a lot of options. I’ve got a roadmap planned out, but it only matters if we get a good result in this first test.
Please keep us updated on what effects this has on you. Keep a journal.
Something else to keep in mind is we don’t know what type of drug/supplement interactions it has to be careful with that too.
With a milligram scale you could easily weigh 180mg and put it into a dropper bottle with some liquid and you’d have the same thing. You’d just need some kind of preservative.
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I was wondering if, given that the 2nd and 3rd only cost $100 extra each (vs ~$750 for the first) we should do 3 dosages from the beginning so avoid it failing because of having the wrong dose instead of because the molecule does not actually work.
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Not a bad idea. Maybe 20μg, 30μg, 40μg?
Or perhaps 10μg, 30μg, 60μg to give us a larger range.
I’ve just placed a poll in at the top of the original post. Neo suggested we do 3 different dosages straight away instead of 1. Vote in the poll for which option you think is best to start with. The rationale behind each choice is listed in the poll.
@Neo @tananth @Hackingbiology.com @Paul_2.0 @katiii @medaura @John_Hemming @Krister_Kauppi @AnUser
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I’ve just placed a poll in at the top of the original post. Neo suggested we do 3 different dosages straight away instead of 1. Vote in the poll for which option you think is best to start with. The rationale behind each choice is listed in the poll.
@adssx @desertshores @Joseph @KiwiGuy
Had to do this in 2 comments as I can only mention 10 people in one comment.
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I’m sure you have all think about this but… If there is indeed a x3 lifespan effect, all three experiment will hit the wall of 1 month of maximum lifespan that the Worm machine has. Maybe it’s better to just try 1 dose to validate the compound?
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We don’t know what it will do to C. elegans. It has never been tested — or if studies were negative, they weren’t published. If we try with one dose, we might pick the wrong one and think the compound doesn’t work, when really it was the dose.
I’m more concerned about whether it works at all (I really, really hope it does). But if it hits a wall, it’s sad that with the 30-day cap, we won’t know how far it could have gone.
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When I planned an experiment, ora said that they can also run experiments to evaluate maximum lifespan. This since worms in my preliminary experiment did not die. Too many were alive at day 30. So medium lifespan could not be calculated.
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If it is true, it is a miraculous drug. I cannot understand how companies interested in longevity have overlooked this molecule.
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The fundraiser link is live! Indole-3-propionamide Dose Response Crowdfunding Campaign – Ora Biomedical, Inc.
@Neo @tananth @Hackingbiology.com @Paul_2.0 @katiii @medaura @John_Hemming @Krister_Kauppi @AnUser
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The fundraiser link is live! Indole-3-propionamide Dose Response Crowdfunding Campaign – Ora Biomedical, Inc.
@adssx @desertshores @Joseph @KiwiGuy @Viracocha @Curious @nikney
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I’ve just contributed US$ 100.
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Amazing thank you KiwiGuy.
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