Took 1mg today with morning shake and coffee.
Update(4/1/2022) I had a sore upper gum and found two canker sores on my upper gums towards to top of my lip. These have been here for a couple days now. they aren’t painful but I did notice them.
@RapAdmin
when one starts getting the canker sores, how do they usually go about taking rapamycin the next period? do they wait 10 days instead of 7 , do they lower the dose? I am only taking 1mg right now but had gotten the canker sores with my last dose.
When I had my one instance of getting a canker sore (Aphthous ulcer) it lasted about 4 or 5 days. I seem to remember it starting a few days after I tried a slightly higher dose of rapamycin, so yes, I pushed out my next dose a few days. This was almost 2 years ago, so I’m a little unsure of the details, I might have also stepped back my dose by 1mg (I was at around 5mg or so when this happened).
I’ve never had another canker sore since then, despite going as high as 30mg+ on a single dose, so a single instance of getting a canker sore doesn’t seem to mean much as far as future side effects.
took 2mg (4/13/2022) , no issues
I’m around similar age and currently planning out the protocol for Rapa, but have been searching into radical life-extension since a long time. I’ve been experimenting with various forms of dietary restriction and supplements.
When you say 1mg then 2mg next month do you mean daily doses of 1 mg or some periodic dose?
Most people do once a week dosing:
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What is the scientific basis for fewer side effects with ramping up from 1 mg to 6…vs starting at 6 which appears to be a well tolerated dose in almost all people. I could understand the need if this were with no track record, but seems by now we have data to say 6 is ok. Maybe even a lot more, so why the ramp up?
We don’t really have much data on it, and people’s responses vary.
Well what if you are someone who has never tried rapamycin and is one of the individuals who doesn’t tolerate the dose but you just start out taking 6mg? Seems like a unnecessary risk when you could just take 1mg for a bit and work your way up to ensure you aren’t an individual who will have adverse effects. Also why would you just start high when you would want to make sure my biomarkers such as WBC aren’t decreasing or having any issues and would want to see how low doses effect you first. It’s more of risk vs reward and you as an individual have to access that risk.
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I do once a week, and have been taking 1mg for about a little over a month now, with only getting canker sores once. I now am moving to 2mg.
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took 2mg yesterday(4/20), ran and had no side effects.
Getting blood work done tomorrow ( 4/22)
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So my lab work is the pretty much the same, other than my CRP decreased from 0.55mg/L to 0.3mg/L since taking rapamycin. I will update on cholesterol results when I get them.
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So wanted to post that after 6 weeks of being on 10mg of a statin and taking rapamycin my cholesterol numbers have gone down significantly. The blood work was taken after a 12 hour fast and two days after taking 2mg of rapamycin.
I am still waiting on Lp(a) and Apo(B) results
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Well you changed up two things at once. Statins and rapa which confounds any good analysis. A good thing to keep in mind as you shuffle things about in the future. Based on what we know this is from the statins. You were in pretty bad shape lipid wise before then.
Yes this is from statins, I was saying about both because I know a lot of people see increase in cholesterol when taking Rapa. I did my blood work two days after taking rapamycin, so I doubt the rapa did anything at the time.
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Took 2mg 4/27/2022, no side effects.
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my ApoB came back as 66 mg/dL
my Lipoprotein(a) was 163 nmol/L which is still very high , but a little lower than my last test on 3/14/2022 which was at 169 nmol/L
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took 2mg this AM(5/4/2022) , had no side effects.
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took 2mg on 5/11 and had no side effects
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Hey @Guywholikessleep , any update on your rapamycin usage? How is it going? Please let us know - we haven’t heard from you in a while.