I saw Bryan Johnson say that he’s been using alpha estradiol lately. I’m not sure if I remember correctly?
Yes - his doctor, Oliver Zolman, helped him get it from the sounds of things (and they mention that it was very hard even for them to get). They made a topical cream from the 17alpha estradiol powder - and that is what he’s using.
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Yes. 4mg wk, transdermal, see post from RapAdmin above:
I think he also discusses it in one of the videos on the blueprint web page
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Sorry for the late update, been very busy with work and training;
my results from 6 march: Estrogen levels 32.9ng/L. 3 weeks later I got it tested again ( so after taking 2mg/ day of 17-a-estradiol for 3 weeks) it had risen to 48,8 ng/L. I got it tested because I experienced acne on my back and shoulders. I stopped taking 17-a-e. and got my blood tested again on 2 may, levels were still 47,9 ng/L. (reference range max 43,2 ng/L). Acne gradually went away after discontinuing the 17-a-e. , were normal 1 month after discontinuing. I think that because I am already taking testosteron, I am more sensitive to acne and starting with a high dose of 2mg/ day also isn’t a good strategy. I am going to do another experiment in october, most probably with a weekly dose of 4 mg transdermal inspired by the Bryan Johnson blueprint dosage. Any thoughts / suggestions are welcome!
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I think if you’re not on TRT, you get a suppression of your testosteron and as a consequence a loss of libido
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there’s another comment on this threat saying it should increase testostrone, because of the hpa axis.
it is hard to gauge whether it increases libido or decreases it based on this thread.
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If it acts as a 5ari it can indirectly increase estradiol which could lead to a lower libido.
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Bryan Johnson’s latest report on his use:
from here: https://twitter.com/bryan_johnson/status/1696944026015117793?s=20
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Bryan Johnson uses the cream version, I think that might be easier then creating the sublingual. Does anyone have any good sources on how to get this ? I’ve had some chinese suppliers try and sell me some ranging from 10 grams for 110USD to 5 grams for 510USD however I think it is kind of a gamble on the qaulity.
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Yes - the Chinese chemical supplier middlemen (of which 99% are - just middlemen) are extremely untrustworthy. The raw powder is hard to get unless you have a friend who works in an academic lab or small commercial lab. The easiest is just to buy the hair product from Europe (where its easily ordered) and apply it topically.
Details here: Alfatradiol - Wikipedia
Just search on Google Shopping for Alfatradiol, or “Ell Cranell”, see example result below:
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I saw on a trt forum a guy was talking about using DMSO instead of transcutol for the trt cream. Usually bioavailiblity of the trt cream is around 10% similar to what you’re saying however with the DMSO it can reach up to 95%. This might be worth looking into. I asked chat gpt for some suggestions and it said 70% DMSO/30% water or aloe. Also to use isopropyl alchol before aplication to clear any particles because it is very effective transdermal absorbtion and you don’t want anything else to be absorbed besides the 17a.
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I would urge caution when using DMSO, since it causes long term changes in skin permeability, so even hours later if you accidentally spill something toxic on your skin, it will pass through the skin.
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Yes - I second that word of caution…
I think DMSO is a little more aggressive in terms of its results than most skin companies want… here is a quote from a cosmetic dermatology textbook:
Another solvent, dimethylsulfoxide (DMSO), by contrast, is relatively aggressive and induces significant structural perturbations such as keratin denaturation and the solubilization of membrane components
See full info and quote in this post: Rapamycin for Hair Growth and Hair Pigmentation - #320 by RapAdmin
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Im not into this topic but last time I had a look, it seems that nobody was realising that there are already 2 supplements on the market that contains E17A.
Both are used for alopecia (topical treatment).
but the ingredients are nothing special and non-toxic if swallowed. In fact they are in other products as well.
Other names for E17A are:
Alfatradiol
minoxidil (a little bit modified, I would prefer a non-altered version if I would use it)
So if one is curious becoming a labratory mouse, bon appetit. 
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Thank you for linking this thread I see now people are using much lower concentrations like 20% DMSO then the 70% I intended do use. I will proceed with caution.
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What if i get 17-a-e powder and mix it in transcutol, and apply it transdermal? Would it practically be the same as mixing transcutol with pantostin?
Yes, it should work even better, if it’s pure. But please be careful as you don’t want to be dosing 17-beta estradiol.
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Oh sorry, I forgot to say “ welcome to the forum" 
Hope you find it as welcoming and informative as i have
Yes - that is a reasonable approach. The issue is its hard to get 17ae unless you work in a lab, or have a friend that works in a lab and can get it for you (order it from a lab supply house).