Yes - that would definitely be the quick and easy approach. But many of us aren’t going to like the results I suspect (see image and paper below). The cost of alpha-17 estradiol is not very high actually - see the quotes from the lab supply companies included in the post. Yes - you are correct in that its not very easy to get - you have to know someone who works at a biology / chemistry organization to order it.
Source:
Tofu has estrogen like chemicals. If you eat tofu it’s possible you could live longer. I remember reading that if you eat four impossible burgers a week you could grow breasts, 
.
Any new clues or updates on dosage for humans, or any reports you’ve found of self-experimentation?
The formulations for topical hair loss applications seem to be around 0.25mg/ml — does it make sense that just 1ml of topical solution is close to the upper limit for the oral dose listed above?
I think the best thing anyone has to go off of are the human safety trials that were done earlier. Here are the calculations of that range and then going up higher.
| Daily Dosing (micrograms, ug) | 50 | 100 | 200 | 400 | 800 |
|---|---|---|---|---|---|
| Total Annual Dosing (ug) | 18,250 | 36,500 | 73,000 | 146,000 | 292,000 |
| Total Dose /Person/Year (g) | 0.01825 | 0.0365 | 0.073 | 0.146 | 0.292 |
standard dose for women of 17-Beta estradiol is 625 micrograms (.625 milligrams) per day.
The more I study these papers, the more I’m unsure of the dosing that would be appropriate for 17-alpha estradiol. The phase 1 clinical study was just a series of single dose tests with 8 women with pre and post bloodwork done. These single doses seem really high - 50g, 100g and 200g… but other papers had tested as high as 70g single dose, so perhaps its real. But such high doses seem unlikely in an ongoing, daily dosing scenario.
While the existing dosing for women of for 17-beta estradiol might be a starting point, its really hard to know what the comparable dosing would be for men, and for 17-alpha estradiol.
In the ITP studies they started out at similar dosing levels for the mice as they did for rapamycin - 4.8ppm, and then 14.4ppm (see below). So - if we take equivalent dosing that people use with rapamycin, we’d be starting at a low dose of 2 or 3 mg/day, and at a high dose as high as 30mg or 40mg, and even to 90mg per day.
Below are the calculations for what the total annual cost of taking lab reagent 17a-estradiol in roughly these doses would look like:
| Daily Dosing (miligrams, mg) | 2 | 3 | 5 | 10 | 20 | 40 |
|---|---|---|---|---|---|---|
| Total Annual Dosing (mg) | 730 | 1,095 | 1,825 | 3,650 | 7,300 | 14,600 |
| Total Dose /Person/Year (g) | 0.73 | 1.095 | 1.825 | 3.65 | 7.3 | 14.6 |
| Total Cost ($160/gram) | $116.80 | $175.20 | $292.00 | $584.00 | $1,168.00 | $2,336.00 |
And here was the rapamycin dosing in the mice:
A rumor brought to you by the American Beef Association 
When I researched this compound, I found that is used as a topical hair loss treatment here in Belgium together with minoxidil, made by a compounding pharmacy. I am thinking of getting this, since I already use minoxidil. That way, I could get 2,5 mg topical per day.
That might help with hair growth - but I doubt the topical 17alpha estradiol will get into the blood stream, so it won’t help you with systemic 17a estradiol.
In topical rapamycin studies they’ve done they found that the rapamycin did not enter the blood stream.
There already are topical testosterone gel and topical 17 beta estradiol gel, and the chemical structure of 17alpha estradiol is similar to them, I wonder if 17alpha estradiol have the potential to be topical use? Are there any clinical data?
Dr Brad Stanfield recently mentioned 17 alpha estradiol , but the information of it is still scarce
Have you experimented yourself 17alpha estradiol yet? Can you share your personal experience to us?
“The transdermal of estradiol in an alcohol solution is unfortunately only 10%” according to the wiki article on estradiol. So I think a better option to have 2 mg tablets made by a pharmacy in my case. But first I will look for some more information on the subject
In the phase 1 clinical study in humans for 17alpha estradiol they just mixed the powder in purified water.
I haven’t tried it, but I’m sure other people have.
Good to see 17 Alpha Estradiol getting some coverage:
I’ve just bought 17-alpha estradiol from Chinese reseller
You don’t need to be in labs or academic institutions, they also sell compounds to individuals
The price is $228 USD/gram, purity >=98%
Thanks for your dosing equivalent table, that’s very handy
I plan to take 17-alpha estradiol on 2mg/day
Are there any cautions I need to know before taking it?
I’ve heard of too many bad experiences with Chinese resellers of supplements, chemicals and drugs to have any confidence in any product coming out of there that has not been tested and validated by an independent 3rd party lab. I recommend you read this post and watch the video attached to it.
Other than that - I think all the material in this thread - from the top post on down, covers most of the known research and tests done on 17 alpha estradiol.
I’ve hit some dead ends trying to get manufacturers to send it to me. Went through a whole process of trying to prove I was a lab, but they wouldn’t send in the end.
What type of information did they want to see to validate your lab status?
First, they asked, “Please provide more information on the company or academic institution that you are affiliated with and what research the item of interest would be used for.”
I work through a corporate structure, so sent them my corporation info and the study info: “Neuroprotective (Aβ-decreasing, anti-inflammatory, and pro-cognitive) properties of 17α-estradiol in male vs female mice.”
That almost worked, but they said my corporate address was residential and they wanted proof of a business lease. I sent them Corporations Canada info on my business address, etc. At that point they backed out, saying, “After further discussion with my management, they have informed me that we would be able to provide our material due to your unverifiable affiliation with an accredited scientific research institution or business.”
Frustrating.
Yes - I suspect that the best / easiest option for us is to look through our linkedin.com network for friends who are working in chem / bio labs at academic institutes / colleges / schools or small companies that do similar types of work and who already have the ability to purchase these types of chemicals.
