I realize many topics here get hijacked by us older members. I’m curious what the under 40 crowd is trying to get out of this stuff? Other than exercise, good diet, healthy body weight and lipid control what are you doing? Is taking 20 supplements really helping you?
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I’m the type who likes to plan ahead and avoid suffering in the long term. By using rapamycin and other medications/supplements I hope to keep myself young and healthy. Besides that, I want to live for as long as possible and experience what the future will bring.
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Start young and keep that aging rate as low as possible. You don’t want to live to be 100 and look like it.
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I’ve always had a very vivid imagination. Seeing older friends and family members around me getting heart disease, cancer, dementia, and then obviously dying, it’s easy for me to understand that I’ll be there one day, and imagine going through it. I also remember my mom telling me when I was young that “an ounce of prevention is worth a pound of cure.” That’s really stayed with me. I realize these are issues everyone has to grapple with eventually, and by being proactive, you can probably get a better results with a milder intervention than if you waited until later when you’re trying to make up lost ground.
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So far im seeing very reasonable straight forward answers. So does this “prevention” require a handful of supplements or just some basic diet and exercise?
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The average American eats a sh*t diet and doesn’t exercise. So, he probably could use a few supplements.
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I’d say it depends on what you mean by “requires.” If your aim is to live a healthy 75 or 80 years, probably a good diet, no smoking, no alcohol, and plenty of exercise is all you need. If you want to live to be 100, it’ll probably take something extra, and if you want to live to be 100 and be vigorous and self-sufficient, it’ll probably take more still. In this case, in addition to good diet and exercise (and, to be completely honest, probably good genes as well), it’ll probably take the longevity toolkit that we have available to us today, which I would say based on my interpretation of the literature is rapamycin, some type of angiotensin II inhibitor, some type of blood sugar control, and perhaps a statin.
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Like others have said, prevention. As a late 30s woman I may be only a couple years out from perimenopause. Given the cascading affects of menopause that accelerate aging throughout the body I am hoping rapamycin can delay or mitigate this inevitable process.
I just started taking rapamycin but other than that and NMN/TMG the rest of the supplements I take are pretty boring like D, K2, Iron, Magnesium, brazil nuts for selenium. Maybe I’ll look into some others mentioned on here after ~six months into rapa.
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I would think picking your parents probably in the top 5 for longevity.
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Unfortunately, I have a hunch that once you hit 80 or so, genetics becomes the most important thing by quite a bit.
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So you’ve gone from hacking to biohacking, love to see it!
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I’ve been trying to teach my kids healthy habits, obviously. The problem is that it’s tough to get them to care “a lot” about longevity when they’re not even 25 yet. At some point I will send them a summary “lessons learned” and they will have to take action on their own. Maybe when they hit 30, and hopefully I’m still around, we’ll have the rapamycin talk.
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Seems like the young folk have their heads screwed on right. I applaud all of you for taking the ounce of prevention route. May we all live a long healthy and happy life!
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Since I was about 26 (37 now) I tried to get healthy and stay ahead of the aging curve. The kicker for me was seeing my grandmother, who had crazy arthritis in her hands, as well as many of my grandfather’s siblings die of heart disease. It all made me wonder what I can do now to prevent that.
I got really into diet and exercise (and fasting at times) during the past 10-11 years and it’s been working well for me lipid and blood sugar wise (except Lp(a)), but I started getting more into supplements about 4 years ago when I learned about and started taking NMN thinking it would provide life extension beyond normal. Even though that’s unlikely to have been beneficial it ultimately led me here to Rapa News, so I’m glad. I originally heard about Rapa on Attia’s podcast, but would never have considered taking a pharmaceutical like this (ie. just buying it from India) until I found this site.
Now I take:
Rapamycin
empagliflozin
Supplements:
Taurine
Glycine
Lithium
PABA
Inositol
Pantothenic acid
B12/D/Zinc
Probably drop soon:
Spermidine
Occasional if I have alcohol:
Pantethine
DHT
Interested/may start at some point:
Statin/ezetimibe to reduce residual risk for Lp(a)
Tocotrienols(same, Lp(a) reduction)
The biggest improvements I’ve seen have been from the PABA/Inositol/Pantothenic Acid combo for gray hair reduction, as well as Tretinoin for facial skin.
Ultimately I think the “young people” on this site are just those with an interest in science, and who recognize the value in well done studies and have a long term growth mindset. We’re probably not that different than the older people, but benefit from the existence of the internet and communities like this one. Wouldn’t you have been all over something like Rapa News if it had existed 20-35 years ago?
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What is this? Is this a topical formulation you purchase, or something you make, or a supplement(s) that you take?
These are regular supplement pills. I gave up on the topical solutions after a while. I feel like it’s not that different from hair dying if you’re applying it every day.
I first learn about Pantothenic Acid and PABA from this paper, and gave it a try after a few months on the Agetron solution. I also tried the Rivertown solution for a while but I believe the cyclosporine in it caused excessive fatigue. Seems like only 30% of people were “PABA responders” so it’s worth a shot, and cheap from NOW supplements. I was taking 500 mg of each, but recently increased Inositol to 2 g. I’ve been taking them for about 3 months at this point.
I threw in the Inositol based on this article, though I wasn’t able to find a paper or anything on it. Seems harmless enough.
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exactly. In my youth, it was books that were hard to find, word of mouth, school, and not much else.
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I’ve narrowly aged out of the demographic for your original question, although I have been unusually concerned about aging since my late teens. My view is that (almost all) mammals age on a predetermined schedule. It’s part of our biology, and that fact alone offends me. The standard range of diet and exercise recommendations are great for maintaining function and preventing or delaying various overt illnesses. So they certainly extend life on average. Whether they do much to modify aging itself though is something I’m skeptical of. Probably some (which?) lifestyle factors have limited effects, but that’s not enough for me.
On the other hand, I’m not convinced that anything else works either. Rapamycin is a contender, and I think taking it has improved my health, but I’m not going to say it made me younger. I could propose experiments with other things all day, but it seems that few people care.
( In case it wasn’t obvious, this comment expresses some views that, while I hope are scientifically defensible, are far from consensus. )
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I think I mostly agree. There are “experts” that say every cell in our body has a clock and when your time is up……
I’m mostly trying to extend health span and lifespan extension will be a bonus if it happens.