I was so happy to learn about these two supplements to add to my Rapamycin 3mg a week is all I can manage to take but got my scan done and it shows that I am not losing and after just 5 months on the Rapamycin and two months on the other two supplements. Next goal is to retest and hope I am increasing in bone density…. My dr had nothing to do with these results but supported me on letting me do what I wanted and just stumbling onto this Rapamycin drug and this group has help me so much!!! Thanks a million.
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Nice to hear Carmen! Can’t wait to see the next scan results.
I too have been helped with a variety of longevity questions, sourcing supplements and options to consider thanks to many on this site. We all move backwards (in time) together. Lol
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A month ago I was diagnosed with osteoporosis, and the report indicated that it looked fairly severe. However, I have always been slim and small-boned, with a BMI of 18, and that naturally makes a difference. A person with a smaller frame and lower BMI is going to have less bone density than someone with a BMI of 25 or 30. Keep in mind your T-Score is a comparison to the average person around 30 years old and your Z-Score is a comparison to the average person your age. Because of this, I was neither surprised nor shocked by the diagnosis, and I do not feel that I need to be in emergency mode. I don’t expect my bone density to ever reach that of the average person, but I will work on the problem.
I am also not changing my lifestyle dramatically out of fear of a fracture. In my opinion, bone quality is more important than bone density, as long as it’s not extremely severe osteoporosis. I have already researched the causes of osteoporosis and the ways in which bone density can be improved, and I plan to make only minor adjustments. My analysis showed that I was getting only about 60% of the RDA for calcium, so I will be making small changes to my diet and supplements to fix this problem. In addition, I will be including more high-impact exercise in my routine to help increase bone density. I expect this to make a substantial difference.
I am also “considering the big guns” meaning various peptides, SARMs, and hormones as possible ways to improve bone density, but this is a complex area with many potential effects and side effects that require careful study. I have investigated the standard medications for osteoporosis as well, but I am not convinced they are necessarily better options than peptides, SARMS, and hormones. They also carry the risk of side effects, and some of them require follow-up treatment with a bisphosphonate once the standard drug protocol is completed. Bisphosphonates have the bad side effect of osteonecrosis (rare or not) which is enough to scare me away.
During this research phase I also looked for YouTube Doctors who specialize in osteoporosis. I found Dr. Doug Lucas. He, like everyone else on YouTube, is selling something. But, his 20 to 30 minute YouTube videos I have found to be mostly useful data with only a brief self-promotion. I recommend you take a look. He has a wide variety of topics. Note: Strontium Renalate is banned in Europe.
I will display what ChatGPT found on bone building drugs for osteoporosis for anyone interested. The common first-line prescription is usually for a bisphosphanate, though, and that is not a bone-building drug. So, it is not in this table:
| Drug (Brand) | MOA | T½ | Dose | Eff % | Bone Impact | SFX | Therapy / Follow-up | Antiresorptive Follow-up | Cost/mo | Ins. |
|---|---|---|---|---|---|---|---|---|---|---|
| Romosozumab (Evenity) | ↑Wnt, ↓resorp | ~12 days | 210 mg SQ monthly ×12 | 100 | ↑↑ BMD, ↓ spine/hip fx | HA, arthralgia, ↑CV (rare) | 12 months; follow with antiresorptive | Denosumab (Prolia, Xgeva) | ~$2,500 |
 Prior auth |
| Abaloparatide (Tymlos) | PTHrP analog | ~1 hour | 80 mcg SQ daily ×24 mo | 90 | ↑ BMD, ↓ fractures | Dizziness, nausea, osteosarc (rat) | 24 months; transition to antiresorptive | Denosumab (Prolia, Xgeva) | ~$1,600 |
Tier 5 |
| Teriparatide (Forteo, Bonsity) | PTH analog | ~1 hour | 20 mcg SQ daily ×24 mo | 85 | ↑ BMD, ↓ fractures | Cramps, nausea, osteosarc (rat) | 24 months; must follow with antiresorptive | Denosumab (Prolia, Xgeva) | $1,300–2,000 |
Covered |
| *Strontium ranelate (Protelos) ** | ↑ formation, ↓ resorp | ~60 hours | 2 g oral daily | 80 | ↑ Spine/hip BMD, ↓ fractures | GI upset, HA, ↑CV (if risk) | Long-term use possible | N/A | $100–200 |
 OTC (EU) |
| Vit D3 + K2 (Thorne, LE, Pure) | ↑ Ca²⁺, osteocalcin | D3: 15h, K2: 3d | D3 2–5k IU + K2 90–200 mcg | 50 | ↑ Remodeling, ↓ fractures | None or ↑ Ca (rare) | Continuous adjunct | N/A | $15–30 |
OTC |
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Good chart: except – no one should take strontium ranelate. It has been banned in Europe because it is carcinogenic. The problem is not the strontium – it is the ranelate. In the US, strontium is available OTC as strontium citrate.
Read the “COMB” study: “combination of micronutrients for bone.” recommends calcium, K (consider both K2-7 and K4),D, and calcium citrate.
Consider a linear vertical vibration plate. Must be vertical (up/down, not side-to-side)
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