I was reading in a book that the best way to make proper human trials for anti-aging medicine is the invention of proper biological clock tests that test aging effectively. It would shorten the length needed for trials for anti-aging.
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Yes - lots of people are working on this right now.
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I’m very glad longevity science is just going ahead on all fronts.
I can’t wait to read through all of the top 100 XPrize finalists health products.
There was one from Australia which is cool for me to see, Exomed, working on an orally bioavailable exosome product: “Exomed’s oral therapy employs regenerative xenogeneic extracellular vesicles from young bovine plasma to modulate key aging pathways. These EVs carry miRNAs and proteins that reduce systemic inflammation, enhance tissue repair, and rejuvenate stem cell function—mechanisms validated by heterochronic parabiosis research. Consumed daily, EVs resist GI degradation, enter circulation, and deliver both local and systemic benefits. Repeated dosing fosters oral tolerance, lowering immunogenic risks. By transmitting “youthful” signals, they recalibrate cellular aging, shifting epigenetic patterns and prompting tissue renewal, improved muscle strength, cognitive resilience, and immune competence. This progressive reprogramming maximises ones functional capacity throughout life.”
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Ok, no worries (extra char)
The XPRIZE Healthspan competition awarded $250,000 each to 40 breakthrough teams developing therapeutics for aging. With 600+ teams from 58 countries competing, we’re witnessing the largest coordinated effort to solve aging in human history.
The following teams have been selected to advance as XPRIZE Healthspan Top 40 Milestone 1 awardees:
A NEW DIMENSION, San Jose, CA
ABE YOANDO PHARMA CO LTD, Adachi, Tokyo, Japan
AGELESSRX, Ann Arbor, MI
ANI BIOME, San Francisco, CA
AUTOPHAGYGO, Osaka, Japan
BIOAGE LABS, California, USA
BIOARMOR, Kuala Lumpur, Malaysia
BOSTON HEALTHSPAN TEAM, Boston, MA
CANADIAN TRANSLATIONAL GEROSCIENCE NETWORK, Montreal, Quebec, Canada
CIRCADIAN, San Diego, CA
EXOMED, New South Wales, Australia
GI INNOVATION, Seoul, South Korea
GODA LAB, Bunkyo City, Tokyo, Japan
HEALTHY LONGEVITY CLINIC, Boca Raton, FL
INTERVENE IMMUNE, Los Angeles, CA,
PROMETHEUS CELL TEAM, Shanghai, China
REJUVENATION THROUGH LOW FREQUENCY ULTRASOUND, San Antonio, TX
RPRGAON-PROGERIA, Busan, South Korea
SANJEEVINI, Mumbai, India
TEAM GLYNAC, Houston, TX
THE HEALTHY BODY AND MIND, St. Louis, MO
TIME TRAVELER AND CURREIO, Tokyo, Japan
TIMELINE, Lausanne, Switzerland
UNIVERSITY HOSPITAL INSTITUTE (IHU) HEALTHAGE, Occitanie, Haute Garonne
VITA, Barcelona, Spain
YOXLO, Oegstgeest, Netherlands JAPAN LONGEVITY CONSORTIUM, Tokyo, Japan
KIMERA LABS, Miami, FL
LIONHEART HEALTH INC, Newport Beach, CA
LOGIN (LONGEVITY INNOVATOR), Sendai Miyagi, Japan
LONGEVERON INC, Miami, FL
LONGEVITY IMMUNOTHERAPY, Irvine, CA
LONO JAEYAK, Gunsan Jeonbuk-do, South Korea
METFORMIN FOR HEALTHSPAN EXTENSION (METHEALTHSPAN), New York, NY
MINICIRCLE, Austin, TX
MITO-TAGS, Palo Alto, CA
MITOCHONDRIAL ALL-STARS, Needham, MA
MITOCHONDRIAL BIOENERGETICS AND KETONE UTILIZATION, San Diego, CA
NUS ACADEMY FOR HEALTHY LONGEVITY, Singapore
NYC-VITA, New York, NY
All semifinalist teams - Top 100 and late-registering teams included - will begin early stage clinical trials over the next year and will submit their data in April 2026 for the next round of judging in the Healthspan competition. Translating findings from the lab to clinical testing is a major hurdle for teams as it requires safety assessment, regulatory approval, testing partners, and investors or funders. In July 2026, XPRIZE will announce the 10 finalists selected to receive the second $10 million milestone prize. These teams will then advance to finals and must test their therapeutic solution for up to one year in adults aged 50-80 years in clinical trials, running from 2026 to 2029. The finalists’ trials will be supported by the University of Utah and its Data Coordinating Center (DCC), which will serve as the DCC for XPRIZE Healthspan. The competition will culminate in 2030, when the grand prize winner is awarded up to $81 million.
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Anyone know how this team plans to measure autophagy? This is the key issue…
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