Has anyone tried the combo?
I tried a small amount of estriol topically on my face for skin anti-aging effects. I didn’t find estriol alone did much beneficial, and I ended up getting erectile dysfunction side effects that went away after I stopped using estriol.
I did find combining estriol cream with estradiol gel topically on the face had a good skin aesthetic effect, but I imagine using this would result in similar side effects so I’m not going to bother.
I don’t see this combination working well for men in terms of wellbeing, though it may have a small lifespan effect.
Not worth pursuing in my opinion.
I wrote my experience report for this self-experiment here:
The only potential way it could be implemented as a man is using it 1 or 2 nights a week in place of a retinoid. I only really experimented with it because I cannot tolerate retinoids on my skin when done every night. I always get redness and dry skin, which is not what I’m aiming for with retinoids. So I was looking for alternative skin actives to cycle through.
Currently experimenting with a home made melatonin face serum which I think is much safer and potentially more effective long term.
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The traditional okinawan (okinawans are the longest lived ppl in the world) diet was over 2lbs of sweet potatoes. I believe sweet potatoes contain phytoestrogens and dhea I think. I think i remember seeing a chart wherr 90/100 yr old okinawans had more of the sex hormones, but i dont remember the details. Anyway, so maybe estrogen is in the equation. But it might be hard to get the dosing right (as you’ve noticed)