World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan

A Japanese research team is making progress on the development of a groundbreaking medication that may allow people to grow new teeth, with clinical trials set to begin in July 2024.

The tooth regrowth medicine is intended for people who lack a full set of adult teeth due to congenital factors. The team is aiming to have it ready for general use in 2030.

In prior animal experiments, the medicine prompted the growth of “third-generation” teeth following baby teeth and then permanent adult teeth.

In experiments in 2018, mice with a congenitally low number of teeth were given medicine that resulted in new teeth coming through. The research results were published in a U.S. scientific paper in 2021, and gained much attention as the beginnings of the world’s first tooth regeneration medicine.

For further information or inquiries about Takahashi’s research, please visit 先天性無歯症 | 北野病院 (in Japanese).

The 2021 paper


This reminds me of the 2010 paper on using stem cells to regenerate teeth.