That’s a really interesting point. The thing we see with vascular disease and men, is that whatever the cause, men have their vascular events a decade earlier - then when women go through menopause we see the women start to do exactly the same as the men.
So what I ponder on this - is that whatever changes make men die earlier might have already happened to all the men by the time they are 40, and testosterone henceforth might not be the active negative ingredient.
I don’t know the answer to this, but just an observation to consider.
I guess “validated” is an important word here as there are none from the most populous countries and none from entire continents. I’ve asked ChatGPT for the likely “unvalidated” number of supercentenarians (3-5 times higher) and Bard/Gemini (10 times higher)
Also, even when “validated” there can be “discussion” as in the case of the no longer alive outlier “jeanne calment” (Only human ever above 120)
The problem is with verification. There may be more people that live to 120 yrs old than we realize.
“Swami Sivananda was born on August 8, 1896, shows his passport. If the information is correct and not a clerical error, the sprightly monk from Varanasi is 120 years old, which makes him the oldest man to have ever lived.”
Given the increasing importance of the genetic component with increasing age, obtaining the complete DNA sequence of all supercentenarians would be immensely valuable. While I acknowledge the ethical considerations and concerns regarding family privacy in sample acquisition, I believe the scientific significance of such data outweighs these challenges.
In the case of Jeanne Calment I have the impression that the “refusal” is partly motivated by the desire of some to expose ID-switching fraud.
None of those people took longevity as seriously as we do. So I expect these records to be broken since some people now care about it, barring some major world disaster.
Exactly, heathspan and longevity research has come a long way in the past 50 to 100 years, and the current state of the art science that many of us here are practicing may make a huge difference.
And hopefully even more so the decisions and things we can do in 5, 10, 15 years given the rapid pace of knowledge and understanding increases as well as in new therapies and technologies coming down the pipeline.