World-first topical gene therapy gel heals decades-old wounds

This seems like it has some potential across other age-related issues:

A Phase 3 trial testing the world’s first topical gene therapy has reported extraordinary results in children suffering from a rare blistering skin disease. The gene therapy gel was seen to completely heal wounds that had been open for years.

Dystrophic epidermolysis bullosa (DEB) is a rare skin disease that results in skin constantly blistering, and often leaves open wounds that are unable to heal. The condition is caused by a mutation in the COL7A1 gene that renders a person unable to produce a key collagen protein.

Unfortunately, because the effects of the gel are not permanent, many patients have seen some of their wounds return in the months after the trial finished. The researchers suggest this is to be expected, but considering there were no adverse effects seen with repeated administration of the gel it is possible ongoing treatments could be effective over long periods of time.

Research Paper (paywalled):