Rapid weight loss by itself, regardless of method, can result in gallstones.
Risk factors for gallstone formation during rapid loss of weight
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From the study.
"The factors identified by this study are useful in predicting patients at high risk for gallstones."
Being overweight is a bigger risk factor than gallstones.
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- At 24 months post-cessation, 56% of semaglutide, 52% of liraglutide, and 55% of tirzepatide patients kept the weight off or lost additional weight.
- Complete weight regain occurred in 23% of semaglutide, 21% of tirzepatide, and 27% of liraglutide users at 24 months.
- Weight trajectories stabilized after 12 months, with only small variations in the distribution of weight outcomes through year two.
As I recall, that’s significantly better than just dieting. One explanation might be that these drugs have long-lasting metabolic effects. To me that has the whiff of something that permanently reverses epigenetic aging by some number of years; if a drug only reverses some aspect of aging as long as you take the drug, then it isn’t really reversing those aspects of aging.
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