Will the GLP-1 drugs promote longevity and healthspan?

#41

What are they? Are they meaningful?

#42

I heard that drug companies typically choose a easy brand name, but indentation lean towards “brutal” names for the “medical” name to make it less easy for generics once the patent life is over

It will likely have a better brand name

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#43

If things are not sterile and you are injecting it at home you run the risk of infections and in the worst case death. Some people have no problems with injections at home though. Personally, I would not want to do my own injections at home.

#44

@DeStrider But are you talking about the auto injectors that brand GLP1a comes with or something else?

#45

Auto injectors are safer. Many people turn one injector into several injections on their own. This has safety issues.

I thought the Indian ones were powder and you had to reconstitute them. This is also problematic.

I prefer the pill.

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#46

Practically very few manufacturers of tirzepatide and semaglutide for injecting are from India . The majority come from China.

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#47

My side effects from even low dose Rybelsus were intolerable. Profound fatigue was the worst part, although I did lose maybe 10 pounds. The published trials for Rybelsus aren’t impressive for weight loss, but if you tolerate it well and you don’t need to lose much, it’s certainly a viable option.

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#48

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Source: https://x.com/statnews/status/1902729927369052345

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#49

BTW I was wrong about the above. Orforglipron is GLP-1 agonist only, so same mechanism as semaglutide not tirzepatide. I’m much less excited about it now, unless upcoming data show it to be more tolerable than Rybelsus for whatever reason.

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#50

Dr, Greger chimes in on ozempic and glp-1RA, and gives some historic context:

Does Ozempic Work?

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#51

I think it’s pretty cool. Reminds me of the rapamycin origin story.

I thought it was exendin-4, and from this they made exenatide.

#52

I wouldn’t call them no hassle. You need to fast for 30 minutes after consuming the pill in the morning, every morning. Or once a week you can do an easy, relatively painless peptide injection.

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#53

Yes, exenatide is the synthetic form of the naturally occurring exendin-4.

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#54

That is so true. For me I used to have the mindset “when I get rich I could use tirzepatide and possibly alleviate sleep apnea”, then I find out you can get it really affordably. Now I’m just using it, and quite honestly the results have been great and I’m excited to continue.

We shouldn’t have to think like “when I get rich I can be healthy”, it’s so sad that so many people must think like this when there are options.

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