A good overview:
Aging is a combination of complex processes influenced by various biological pathways, one of which is the regulation of nutrient sensing. The “Hallmarks of Aging” framework identifies deregulated nutrient sensing as a key contributor to aging [1]. Four primary nutrient-sensing pathways regulate metabolism and impact aging: the insulin and insulin-like growth factor (IIS) pathway, mechanistic target of rapamycin (mTOR), sirtuins, and AMP-activated protein kinase (AMPK) [2]. These pathways are termed “nutrient-sensing” because their activities are modulated by nutrient availability. Dysregulation in these pathways can lead to metabolic imbalances and accelerate aging.
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