Researchers identified over 400 genes tied to various forms of frailty, offering fresh insight into why people age differently. The study highlights six distinct pathways of unhealthy aging, opening the door to more precise, targeted anti-aging interventions.
Journal Reference:
- Isabelle F. Foote, Jonny P. Flint, Anna E. Fürtjes, Jeremy M. Lawrence, Donncha S. Mullin, John D. Fisk, Tobias K. Karakach, Andrew Rutenberg, Nicholas G. Martin, Michelle K. Lupton, David J. Llewellyn, Janice M. Ranson, Simon R. Cox, Michelle Luciano, Kenneth Rockwood, Andrew D. Grotzinger. Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling. Nature Genetics, 2025; 57 (8): 1848 DOI: 10.1038/s41588-025-02269-0