I have a question regarding the dosing protocol for Rapamycin.
It is well-established that for longevity purposes, oral Rapamycin is typically taken once a week (e.g., 5-6mg) to allow for a “washout” period, which helps avoid the continuous inhibition of mTORC2 and minimizes side effects.
However, I’ve noticed that most non-oral formulations—such as topical creams for skin or toothpaste for oral health—often recommend daily application.
My specific questions are:
Systemic vs. Local Effect: Is daily use of topical considered safe because the systemic absorption is too low to suppress mTORC2 throughout the rest of the body? Furthermore, even if systemic levels remain low, could chronic mTORC2 inhibition within the local tissue itself lead to negative side effects
I would love to hear from anyone with experience in pharmacology or those who have experimented with different Rapamycin delivery methods.