I am more concerned that Misha developed cancer in spite of taking Rapamycin for years. He was a smoker, but Rapamycin should have been protective?
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33.1 to 18.8
Weight stable for 4 years
79kg to 45kg
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You can calculate bmi easily online.
Far from a whale. I’ve never been over weight in my entire life, just the opposite. 5’9-1/2" height, High school-150lbs; Now-156 I’d followed CR Society (among other longevity organizations) and dietary recommendations based on Walford’s Beyond the 120 Year Diet and intermittent fasting. My weight went down to 148, but I felt great. I must disagree with you however, as pursuit of longevity will be a battle of appearance versus the inevitable progression of time and your window of perception is too limited.
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This is exactly what also worries me. Could it be a wrong dose for too long that over suppressed his immune system?
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holly just 45kg, Sounds like you on road to disappearing lol. Good for you if that is the optimal weight for your height and composition, but holly molly dude you basically got rid of 50% of yourself. hahaa.
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@John_Hemming I was as high as 30 bmi 15 years ago. I am now 26 bmi with a body fat % of 16% measured by Dexa. I don’t think bmi is useful.
Muscular people have high bmi.
Skinny fat people (high fat but low muscle mass) have low bmi.
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I was not muscular at 130kg
I agree 100%. I’m quite happy with my musculature and athletic status at age 67. My face makes me look older. In my youth I (stupidly) played a lot of cricket in the Australian sun and also worked 5 winters in the snow without UV protection. Consequently I have a face that resembles an old leather boot!
I really hope that damage due to UV light has not translated into body-wide damage. We know that “sunbathing” damages the skin, but it is probably also damaging blood cells and cells of blood vessels near the body surface.
I also remember reading a paper in which people were asked to guess the ages of others by facial photos. Diabetics were consistently judged to be older in appearance than non-diabetics of the same age. So I guess diabetes accelerates facial aging.
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This might work for those with average body structure but it gives useless/wrong results for others who have different body composition. I guy I work with is 1/2 inch taller than me and weighs couple LBS lighter than me. He has a huge belly, I have none. So, one day the subject of weight came up and he goes I really need to lose some weight, I said make that two of us, and he goes are you kidding me, I wish I’d weigh as much as you do. I said I guarantee you that you definitely don’t want to wish that. Told him my weight and goes absolute lie. I said ok lets bet that if I weigh more than you pay for a nice steak dinner, If you weigh more than me I’ll pay. So, we went to stop&shop where they have a scale, he weighs 241 lbs and I weigh 243. He couldn’t believe it, and thought I was doing some trick or something, he even checked if i had some metal in my pockets LOL.
Long story short all these arbitrarily BMI calculations are very misleading for a lot of people.
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On a population basis BMI is useful, on an individual basis, you can have increased visceral fat and have a BMI of 22 and be metabolically unhealthy.
One quick item, which works pretty well, in screening for a healthy body makeup is waist circumference to height being <=50%.
DEXA is absolutely the way to go. The group Dr. Kaeberlein uses which are in Seattle, San Fran, LA and I think another couple of places allow DEXA’s for $39 each. It then becomes affordable, repeatable, etc.
In Nashville area, it has been ~$200 - however we have a new group in town opening in 2 weeks, that is doing them for $75. So my wife and I are doing them on the 15th of July for the first time. For us, this ends up being okay - but for a repetitive test, I really like the $39.
For those not inclined to do this, the waist/height isn’t a bad option.
On Dr. B, the issue of how he looks isn’t really attributable to Rapa, same thing with Dr. Green —- he’d probably have been dead long ago without it. People with chronic significant disease are not going to look well.
The other thing is even isolating what the active ingredient is, as virtually no one just does one thing. I don’t have a single patient who has a strategy for longevity, that their only intervention is rapamycin.
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I remember him saying he had a tumor mass 20+ years ago so he worked to make sure it didn’t become cancerous for so long, and thinking the rapamycin prevented it from becoming full blown cancer for so many years (or something along those lines)
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ha, this really interesting. I’m 6 foot and waist of 35 (normal 34) less than 50% so there is no way my BMI is 31 or 32 then as the scale is calculating it.
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You BMI is a simple calculation of kg/meter^2 height …. The issue is this doesn’t account for whether you are at a healthy weight for you. For example, someone with lots of muscle mass can be 6 ft, 220 lbs and have 10% fat, no visceral fat — and will indeed have abd/height <50%.
Conversely, you can be a couch potato, 6 ft, 180 lbs, 35% fat and have a better BMI, but be metabolically very unhealthy, and your waist to height will generally be >50% in this situation.
DEXA gives an exact measure however.
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Agreed.
It sounds like you have a similar body composition to my husband. He doesn’t have a gut, has a lot of muscle and a bmi of 31. BMI is lacking in nuance at the individual level.
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@DrFraser Awesome. The Dexa scan report I received provided an amazing array of data points including fat weight, volume and area in a narrow slice of my abdomen which it defined as the Visceral Adipose Tissue.
Apparently everybody has a unique level of fatness that doesn’t push fat into the organs or abdomen. But once the fat goes there, the metabolic problems begin. My healthy fat amount is very low (I believe) so even at 16% body fat I have too much visceral fat. I’m working on it.
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The interesting thing is that subcutaneous fat is metabolic inert, but visceral fat is metabolically active, and in a bad way. Everyone has a fat threshold, and it is gender and race specific. It is also determined by estrogens, which is why men get NAFLD 10 years earlier than women, but once women go through menopause (assuming they don’t take HRT), the ability to pack fat on subcutaneously ends up going more to the limits that males have, and now that subcutaneous fat becomes visceral fat with all the bad outcomes associated.
This is why women end up getting fatter in the middle even if maintaining the same body weight with menopause and start getting NAFLD, diabetes, heart disease and all the metabolic syndrome stuff …
It is an interesting area - also BMI’s by race - where Asians for example have lower ability to pack on subcutaneous fat, so at a given BMI or %fat, there is a lower threshold for this to then become visceral fat with the bad outcomes associated.
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Apparently not all women get fatter in the middle. I did not. My waste is the same as when I was 20. It’s 28-29 inches, and my stomach is flat. I don’t have diabetes, while on Rapa for a long time. I never had hormonal therapy, and I’m not Asian 
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The issue is that if you had subcutaneous fat that was moderate, if you let your estrogen go low (e.g. didn’t pursue HRT), then some of that subcutaneous fat would move to being visceral fat. But you have to exceed your personal ability to store subcutaneous fat for this to occur. When one loses estradiol, that personal threshold goes down - however, if you don’t exceed that threshold, then you still don’t have this body change, but most women do, and have a body morphology change occur with menopause.
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Sabrina wrote: “Have you seen anybody on rapamycin who appears youthful?”
Huh???
Just saying I’m a little “butthurt” that my name didn’t come up on this topic. Lol
I’m definitely getting people thinking I’m 50 actually age is 66 years. And, I’ve been on rapamycin going on four years. And TRT 200mg… 1 ml injection weekly.
My family, my friends, staff at work, everybody sees it. Which is why some of the doctors at my university have been asking me about rapamycin, and have since gone on it.
For fun, what I think I would have looked like with no rapamycin past 4 years.
How I actually did look before Rapamycin July 2020.
And how I look now March 2024.
Skin thicker and better (I use a .2% rapamycin cream)… cartilage in nose and ears strengthened, hair thicker… extra fat… gone.
You be the judge… more youthful appearance? As I said, I want rapamycin to make me look good, not good for my age. Hahaha 
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