That’s a good point. Also if people have very limited ability for prevention (limited time or resources) then knowing what to prioritize can be useful. This is in contrast to most of us that are super interested in longevity and try preventing everything.
I think all sorts of things have trade offs and hormones come to mind most obviously.
Estrogen is neuroprotective (and bone protective) but potentially a cancer risk factor. Say you have strong family history of breast cancer and AD - my sister.
Testosterone if you have a very low risk of CVD or higher risk of osteo or sarcopenia.
Tadalafil has good evidence for CVD protection but potentially harmful for LBD or maybe AD.
Some of these are all debatable but lots of things would seem to be harmful in one category and beneficial in others.
And never discount that some people are okay to die of CVD or cancer but don’t let them have AD. Or whatever preference for 1 disease over another that might not always be rational.
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This is my new go recommendation for whole genome sequencing for two reasons:
First, they put a high value on privacy:
Second, their new .genome data format should greatly improve LLM token efficiency when analyzing a genome:
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what are the differences between 3x, 30x, and 100x?
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These posts in this thread give a good idea:
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Perhaps of interest to everyone here doing WGS: Ronjon Nag, Just Announced Superbio.ai - lets you work with large-scale data — genomics, proteomics, etc. 100GB+ — by asking questions in plain English
Anywhere to get whole genome sequencing in Australia?
If you use sequencing.com watch out for unexpected charges as a trial membership gets converted & billed as Premium (without notice). They don’t tell you that you can change your account setting to a free account.
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Many thanks for this warning on sequencing.com. I was indeed charged $39 in the months of June and July. When I tried to opt out online, there was no option. When I called customer service, I was offered a number of scammy business offers and never connected to a customer service rep. I just wrote the email now asking for them to cancel the service and reimburse me. Very disappointed in this company.
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Happy to report that sequencing.com agreed to refund both charges immediately.
I am updating my view of the company from disappointing to somewhat wary.
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Some other ideas for approaching this issue:
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