Which supplements do you think are still worth taking?

Supplements
#223

Yes I’d agree with that. Depends on your goals -

are your optimizing for longevity in the long run (then don’t want too many growth factors (mTOR, IGF-1, etc constantly revved up), and inflammatory process and wear, etc)

or

are you optimizing for max athletic performance (of a given sort eg the amount (and type) of muscle would be very different if goal is marathon, vs 100m sprint, vs weight lifting records).

Clearly there are overlap where a certain amount of exercise, protein and muscle training is helpful for longevity in the real world for humans (in a non sterile lab). But the optional amount of protein is almost certainty different for max muscle vs max longevity.

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#224

One recent example by the Lamming Lab - one of the top scientists in the power of rapamycin, longevity expert, etc and followed and respected by many on these fora:

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Here is the paper in a top journal:

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice: Cell Metabolism

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00374-1

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#225

I would never take health advice from someone that looks like this. This isn’t a cheap ad hominem either but clearly whatever they are doing isn’t working

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#226

That’s why I only listen to people who have heart attacks at 50 years old when looking like this.

image

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#227

Arterial plaque takes decades to form, not a few years.

But of course you can fake looking healthy with PEDs, so not everyone looking healthy is healthy but nearly everyone that looks unhealthy usually really is

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#228

If you really push your LDL or apoB to the limit, it will happen faster, as sometimes happens on the carnivore diet if the fatty acid composition isn’t towards more unsaturated fats.

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#229

What do I still take apart from Sirolimus?

Metformin
Taurine
Klotho
GDF11
Astaxanthin
Captopril (Just swapped it for Enalapril)
Vitamin D + K2
Glucosamine + Chondroitin

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#230

How does a person get a low isoleucine diet without low Leucine as well? I cycle my protein around rapa dosing, and I’d be particularly interested in very low isoleucine in general if I could fight out how.

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#231

Where do you get you Klotho from?

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#232

It is a very rare to see atherosclerosis already in the 4th decade in people with some lipid disorders (where you only start seeing in the 2nd half of the 3rd decade) because plaque formation takes that long

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#233

Don’t know about you, but the girls look pretty cute to me. Sure I’d take advise from them!

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#234

Should’ve perhaps replaced his saturated fat with carbs and seed oils.

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#235

so, we’re back at it I guess (lion vs wilderbeast, carnivore vs herbivore) . Yeah, let’s just put this to rest and eat whatever you like :smile:

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#236

I’m of the opinion that you can eat whatever you want as long as you keep your blood parameters in optimal range, aren’t overeating and get enough protein and fiber.
If you’re addicted to sugar, eat your candy with acarbose. If you can’t go a day without eating a entire cow, get on a statin.

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#237

Buckylabs in the USA.

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#238

Thanks, My email to them is on its way.

#239

My go-to non-prescription tranquilizers In order of my self-perceived effectiveness:

Cut out coffee, but that is never an option for me.

Of all the things on the list below, I think lithium orotate is the best long-term solution for anger issues. For me, it dramatically reduced road rage issues and the tendency to fly off the handle.
Lithium orotate and exercise are my solutions for long-term anger management. And, as a bonus, it may extend life.

Lithium orotate: 10 - 20 mg elemental lithium. Takes weeks and you need to maintain it.
Gaba + Taurine: Works in 60 minutes or less
l-tryptophan: Works in 60 minutes or less
l-theanine: Works in 60 minutes or less

Oddly enough, I feel quite tranquil after a workout at the gym.

Nootropic: phenibut, Works in ~2 hrs but lasts. “It acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors.” IMO: Much more powerful than a GABA supplement
Works very well and addiction is a remote possibility unless you use a lot and take it every day. Even if you were to get addicted, it is not that hard to titrate off.
Which kind? Phenibut HCl or FAA: Which Is Better?
“This depends on availability and reason for use. For instance, if you’re using phenibut to improve your mood, HCl might be a better choice because of its high solubility and cost effectiveness. You can dissolve it in anything, and long-term use won’t break the bank.”

It’s a little hard to source in the U.S. but you can get it from Russia. ( Actually, I have bought many nootropics from Russia over the years with no ill effects. After all, Russians invented most of the useful nootropics.)
Actually, everything seems to be back-ordered. I don’t know where to buy it at this time. There is one U.S. seller that claims to have it in stock, but they want too many personal details so I am not going to reference them.
https://science.bio/?post_type=&s=phenibut

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#240

What is the dosing for Klotho from buckylabs?

#241

Not sure I think he is “giving advise” vs more pursuing scientific research and sharing that with the world via high impact papers…

…But are you saying that the scientific impact of scientists is negatively impacted by how they look from a fitness perspective rather based on their intellectual abilities and that you will not weigh their research and scientific contributions?

If so you probably cannot rely on a lot of data or science on your longevity journey or at least will have massive holes vs the potential data and scientific insight you could otherwise leverage.

In any case, in don’t know Prof Lamming, but do know that he is contributing more than most in the world to understanding rapa, rapalogs and mTOR in the context of longevity. Which I’d think we in this forum should herald.

In any case 2, I don’t see any value in you posting statements like that that just seem mean and petty about anyone, let alone someone who is just trying to help the world become healthier.

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#242

An old geezer rant :sweat_smile:, but mostly true:

The FDA is another failed government agency, firmly in the pocket of big pharma.

It wants to protect us from ourselves but does not want to protect us from big pharma’s unproven vaccines.

Why you can no longer get phenibut:

Product discontinuation

November 15, 2023

Dear Valued LiftMode Customers,

It is with deep regret that we announce that we have had to discontinue the sale of our Phenibut products.

For over ten years we have fought hard to support autonomy, and to keep well-being decisions in the hands of the individual. We have striven to provide (and preserve) access to the newest, purest, most research-backed and impactful ingredients with an unwavering commitment to quality and lab testing.

We have kept our ears and minds open to what our customers want, and we put our talented team of biochemists and nootropics specialists to work, consistently developing new formulations to meet these needs.

These guiding principles remain unchanged.

At the same time, the FDA and public sector agencies have steadily and strongly increased actions aimed at curtailing the remaining availability of Phenibut – making unmistakably clear they prioritize and will aggressively enforce their earlier finding and ruling that: “phenibut does not fit any of the categories of dietary ingredients under the The Federal Food, Drug, and Cosmetic Act (FD&C Act). Any dietary supplements that declare phenibut as a dietary ingredient are misbranded”.

The costs and consequences associated with these conditions and developments have left us with no viable option than to permanently end the sale of Phenibut, effective immediately. We humbly apologize for the inconvenience this may represent for many of our customers, and pledge that we will do our absolute best to continue to develop new offerings and continue to be of service to you looking forward.

The FDA will continue to come after our supplements, especially if they happen to work and big pharma views them as a threat.

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