CRL1505 (formerly Lactobacillus rhamnosus CRL1505) is noted as an immunobiotic probiotic strain isolated from goat milk, extensively studied for its ability to prime the immune system and clear infections. Research indicates it beneficially modulates the inflammation-coagulation response in the respiratory tract, offering protection against pathogens like Streptococcus pneumoniae, Klebsiella pneumoniae, and respiratory viruses.
I have been using Life Extension’s Florassist Immune and Nasal Defense for many years. In the US, they appeared to be the only supplier. Today, I learned they have dropped the product. A light AI search suggests that the product is available in Italy and Finland, and perhaps Argentina where some of the research has taken place. Does anyone here have a supplier of the CRL 1505 strain?
A recent small but reasonably well-designed RCT for those unfamiliar.
Life Extension still has one product with 50mg (100 million CFU) of CLR1505 Life Extension Immune Packs. It is basically daily packs consisting of “Immune and Nasal Defense capsule” + 3 other capsules (basically zinc, vitamin D and vitamin C w/ Quercetin) for $28.50 per 30 daily packs, with subscription. Since Immune and Nasal Defense is no longer available separately, I assume this will phase out after it sells out.
Thanks for the tip. I ordered a few bottles of the Nasal Defense formula, hoping that I get the product. I’ll know later today. LE has quietly substituted orders for it with their mushroom blend – ~same price. I have had Amazon follow suit on such switches with other products so we’ll see whether the order is fulfilled with existing stock.
Perhaps with enough weight of interest, Life Extension might bring the product back. I’ve been a member for about 26 years. I will give them a call and email if we have enough interest here.
Great idea. Let me know what your hear and I can follow up with a call if you think it is worth it.
On the other hand, I am wondering if they dropped it for a reason beyond business/economic. I have seen them quietly drop expensive ingredients before. Some times it was for a substantive reason but at least as often, it was to reduce production costs or because of a partnership squabble.ubstituting.
…“in 1983, two researchers at Tufts University in the United States, Dr Sherwood Gorbach and Dr Barry Goldin, had isolated a strain so robust that they patented it. They called it Lactobacillus rhamnosus GG — “GG” standing for their initials.”…
The GG strain is the most widely studied strain of any probiotic and is mainly used for healing your gut after antibiotic administration and maintaining gut health. The GG strain has pili (small hairs) that facilitate rapid colonization of the gut after antibiotic administration.
However, the GG strain does not have the proven respiratory immune boosting properties of the CRL 1505 strain.