Some medications and supplements should be taken in the morning. Others in the evening. This is a good place to help us to determine the optimal times to take meds/supplements.
I’ll start with this video. I agree with her recommended timing. It’s a short less than a minute video about common supplements.
Maybe. I mean timing may certainly matter, but I’m less sure about these specifics. Some are very clear cut, like caffeine, which acts very quickly and persists for a defined period of time (depending on how fast a metabolizer you are). But she says things like vitamin K2 for bedtime relaxation - the effects of K2 is very different depending on form, with MK4 in the blood for only a few hours in contrast to MK7 that’s long lasting. And others taking a long time from ingestion to final effect as it is mediated through gut bacteria. Rather than timing for day or night I think it’s even more important to pay attention to non interference as some supplements and medications should be taken away from each other and that’s why I’d take some in the morning and some in the evening, to keep separated and not because mornings or evenings are key.
My opinion won’t be popular but I think all of this navel gazing just feeds the addiction. I don’t want to be highly skilled at taking supplements. I want to not need to take supplements. It’s solving the wrong problem, and thereby getting caught in a doom loop.
Maybe thats just me.
I hear you. But have a different view. I do all I can to optimize my health anyway. And what if I want to extend it beyond what can be achieved by those means? That’s where drugs and supplements enter. Not wanting to need supplements is a nice want. But if I want to get from LA to NY as fast as possible, I will need to use an airplane, wanting not to need one will never get me to run as fast as that plane and flapping my arms won’t let me fly. I want the equivalent - I want my health and longevity to fly, not just run. My airplane are drugs and supplements… at this point, but on the horizon are genetic engineering and body technology - so:
Long live unnatural! Long live Civilization! Long live life extension! Long live beyond normal! To the stars and beyond! Dream of the immortal! The heck with this frail and imperfect body! Augment Improve and Engineer!
Supplements are there to get me beyond what can be accomplished without them - today. It’s in the very nature of the concept. Supplement. Add. Boost. Beyond. I want it. Of course, YMMV, and to each their own.
I gather that it’s not just me though, which is why this site attracts so many 
!
I typically set all my pills up for the week in advance, taking a portion with breakfast, dinner, and before bed.
I normally take half doses of each with breakfast/dinner (for ex: 2g taurine 2x per day), and then take most meds like rosuvastin, Ezetimibe, Telmisartan, nattokinase, etc right before bed.
I favor a weekly schedule when I can. The only medication I have to take daily are my statins, and I may look for ways to take a massive dose weekly. I haven’t looked at how effective that is.
My preference for a weekly schedule has been a major obstacle in adopting an SGLT2 inhibitor (and leaning towards a GLP1 agonist) since the half life of this medication is about 12 hours.
@CronosTempi I think that is a fine short term strategy. It’s the long term use of the crutch that I object to. I try to teach my body to give me what I want. I see only two long term uses for drugs/supplements: (1) to correct for errors my body makes that I cannot correct (genetic, wear and tear, etc) and (2) chemicals that my body can use in unnatural amounts …more than I can get through food and endogenously, such as creatine.
But as you say, to each his own.
Your point is well taken.
At age 72, I apply a different calculus than most younger people. I’m willing to be more speculative as long as the risk of harm is low.
Also, not all of us react to K2 MK4 the same way. If I take a typical K2-MK4 dose, I don’t sleep. So heck yeah, I take my mcgs of K2-MK4 in the morning. (As is so often the case, I post for those of us who live in the tiny rooms at the edges of the bell curves.)
Yes, I agree. As long as the downside risk is small then any miscalculation won’t undo a lot of hard earned gains.
The only thing I’d pay close attention to is to avoid supplements high in antioxydant close to working out. Take them at least 4+ hours after exercising to not blunt exercise benefits
I think the issue is what is normative versus what is optimal. And filling that gap may require supplements. However, as I have said on this forum before, the science is just not there for individualized medicine vis-a-vis various nutrients, polyphenols, etc.
I’m sorry but I think this is what Attia calls majoring in the minors.