I hear you but what works best for me (meaning the way I may feel) may not be best for longevity purposes, and that is my dilemma. I’ll have to do more research in terms of med’s 1/2 life and mechanisms of action etc… to try and come up with a more educated answer/approach. I might play around a bit. At moment thinking of doing glucose lowering ones (ACA, Metformin and SGTL2i on RAPA day and 2-3 days after and stop them for the rest of the week or maybe stick with only one and stop the other two, and probably do the same with the lipid lowering ones.
Playing with doses and regimens is probably best done by people who have access to frequent doc checkups and frequent lab work so they can measure the results to try and find the sweet spot. For most of us (including me) that do checkups annually we might be shooting in the dark (without data to look into).
Like you, I find myself doing ad hoc cycling plus some that is slightly more evidence based. I can appreciate that some of us might want to develop and adhere to a more strict cycling calendar; however, for most of the geroprotective substances we are experimenting with, almost any such calendar invokes a degree of misplaced confidence. We find this kind of misplaced confidence amusing when we observe a non-scientist reporting the mean of a handful of +/- 20% estimates out to three decimal places. Not much different in this realm. Exceptions would obtain if you are taking precision measurements and following a rigorous methodology, which is a great thing to do if you have the interest. I find that I lack that level of interest i this area of life.
I take my statin and some supplements every other day to avoid side effects. Just realize that taking a prescription drug every other day lessens it’s effectiveness but may also reduce side effects.
I imagine you’ve seen the thread on this, but incase you haven’t, Good labs is a site where you can request dirt cheap labs on your own, with no doc involvement. Their AI will even analyze them for you (not that you need that part). Also, in NY, if you donate blood, many of their labs will be free (I imagine you just tack on the additional ones you might want).
For your first order you can get 20% off with a code… I have one or I’m sure many others do as well.
Great… and here is a helpful hint because I was just ordering labs for my brother in DC… check Labcorp against Quest, even when purchasing them within Good Labs.
I use Quest here, and when I was ordering labs for him at Labcorp through Good Labs, I was shocked at some of the prices, so I then compared those to using Quest and it was vastly less expensive. Perhaps there are regional differences, I haven’t checked.
Interesting. I have only used goodlabs once but I don’t think it gave me options as to where to perform the test themselves. It directed me to a different name altogether and it was called Bioreference labs. Next time I do lab work I’ll see if it allows me different options.
Actually, I just realized that and yes LabCorp seems cheaper than Bioreference. Next time I’ll pick LabCorp. Thanks for the heads up, as i mistakenly thought there was only one choice-bioreference.
edit: no, quest is way cheaper than both, I hadn’t checked Quest yet LOL
Clearly only Bioreference is supported in NY/NJ. I’m pissed would have been way cheaper with quest, over $100 saving compared to bioreference for same tests.
“For NY and NJ, only the Bioreference lab is supported. Please enter a zip code outside of NY/NJ or select the Bioreference lab”
@SilentWatcher I found your posting interesting would you mind elaborating.
What would you consider an ideal scenario of taking metformin, in a time frame of one week as an example. i.e. the dose, how often (morning or evening), in combination with what typical diet, and amount of exercise etc.?
Good Labs is not available in my area. I use ultalabtests.com; they are significantly cheaper than LabCorp or Quest. They are very straightforward, and you can choose either LabCorp or Quest to have your labs done. Quest price for CMP: $44.10; Ulta Lab price: $22.95
Not available in NY/NJ where I live. Could’ve done CT (not too far from where I live) but I’d called a while back and they told me I needed to show a CT ID. Kind of suck because they are pretty cheap. Stuck with Goodlabs bioreference which are about 30% cheaper than going with LabCorp or quest directly (in my area/state). still more expensive by about 30-40% than other options in other states.
Scientists in the US and Germany used data from a long-term US study of postmenopausal women. Records for a total of 438 people were selected – half of whom took metformin to treat diabetes, and half who took a different diabetes drug, sulfonylurea.
While there are some caveats and asterisks to the study, those in the metformin group were calculated to have a 30 percent lower risk of dying before the age of 90 than those in the sulfonylurea group.
“Metformin has been shown to target multiple pathways of aging and therefore has been postulated as a drug that may extend human longevity,” write the researchers in their published paper.
Yes, metformin is much better than sulfonylurea. No one should take the latter when they can take Metformin instead. Do any doctors.still prescribe it?
