Sure, but ritonavir and itraconazole both seem to have a good record. Ritonavir is daily medicine for HIV suppression, so thousands take it daily for years (available sine 1996) and itraconazole is probably one of the most widely used antimycotic medicines on the market from late seventies, still similarly to ketoconazole might be liver toxic (safer though) and with longer half life that would probably affect rapamycin metabolism more in terms of expanding the AUC, but it is available in Europe and quite reasonably priced. Ritonavir is a very potent irreversible inhibitor of CYP3A4 and would probably extend AUC even longer. In any case I would not take this two regularly without testing my rapamycin serum levels and effect on my body. Rapamycin absorption and metabolism depends so much on individual organism that adding variables in form of CYP3A4 inhibitors makes things even less predictable.
With GFJ which is the simplest of all since it inhibits CYP3A4 mostly in intestine and thus increases mostly absorption but not AUC is probably the safest but again it might be too variable in CYP3A4 inhibition? IDK.
I did not A-B test forms of GF, just a binary experiment and blood tested post several times.
Blended into water 6mg, took in the afternoon, blood tested 8am next morning. = zero in my blood
some have said blood test 2 hr post taking rapa.
I tested 12-20mg and best I saw was 0.5-2ish. Yes some say I should test 2 hr post rapa. But given 62 hr half life I figured next day 8am I should see most of the peak… ???
Caned frozen pink GFJ from Kroger + kitchen sink of other suppressers; 1g berberine, 20mg of peperine, quercetin (may not be needed), Fisetin(not sure this either), I’m Kitchen type. Blended and took in the AM and set a 2 hr timer.
noonish took 15mg rapa 2 hr after GF mix.
2 -3 hr after rapa had Labcorp sirulimus test blood draw.
Eureka; 20-30 (?? some units) of sirulimus reported in my blood.
A few other scenarios and a few other blood tests and blood levels between 0.2 up to highest seen 40…
Given N=1 variable blood levels, I’ll guess that folks here (etc) are seeing a wide range of absorbtion!!! Some here I’ll guess are getting zero benefit due to low absorption.
I would suggest that any study that blood testing be done on all participants and then participants use that protocol every time. IE I have compliance and consistent timing variances. ;(
And what blood levels should we be targeting? :> :> :>