https://www.ejinme.com/article/S0953-6205(24)00375-3/fulltext
8.0 is threshold for mild IR
rapamycin at high enough doses can induce IR, increase TGs, and also decrease LDL-R (increase LDL)
We included 12,074 participants with a mean age of 46.91 years; of these, 50.25% were female and 49.75% were male. Each 1-unit increase in the TyG index was associated with a 1.64-year rise in Klemera-Doubal method (KDM) biological age and a 117% higher risk of accelerated aging. Similarly, each 1-unit increase in the TyG index corresponded to a 0.40-year increase in phenotypic age, resulting in a 15% higher risk of accelerated aging. The analysis also revealed nonlinear positive relationships between the TyG index and biological aging, particularly for KDM biological age and phenotypic age, with a turning point at 8.66. Across all subgroups, the TyG index consistently showed a positive correlation with biological aging, even in the presence of significant interactions.