What were your days or weeks prior to the test like? Was this immediately after a fast or after rapamycin administration? I wonder about the variability of the such age tests and how it can change day to day based on behaviors followed during these days.
After, but like, rapamycin didn’t change anything when there wasn’t really anything to change to begin with (regardless, I’m not risking it)
The biggest change is melatonin megadoses driving down my blood glucose (but need to check again with a CGM) since my HbA1c was historically 4.9 and could be a few points lower
On 4/21/2014 my results are:
my RDW and MCV decreased from 2014
But MCV was 99 on 02/10/2020 and then 93 on 11/11/2020 so it’s not terribly diagnostic of age.
RDW was 12.3 on 02/10/2020 and 11.7 on 11/11/2020
% Lymphocytes was 33 on 02/10/2020 and 39 on 11/11/2020
I definitely went more aggressive on the rapamycin at one point of time but can’t remember when I went up to 10mg/week (and then to 20/mg every 2 weeks with grapefruit)
Alex - are your blood test results from after fasting for 12 or more hours?
Also - were you taking (or had you taken any) of the medications in the day prior to testing?
Least youthful value is Alkaline Phosphatase, which was 90 on 11/11/2020 and 70 in February 2021. It has a low coefficient but I want to look into that. I have ALP measurements of 60, 68, 90, 70 (measurements from 2020-2021). I have no clue what it means. I may have to detox more than others (b/c of all the vegetables and odd drugs I take).
I only looked up the significance of RDW yesterday and was surprised that its coefficient was the HIGHEST (of all things). Its the least obvious measurement, but thankfully I have super-youthful values here that have DECREASED over time.
Did you measure CRP levels in your blood too?
0.03 from OpenCures July of last year (which could be even lower b/c hsCRP is so bad at the low end). Most measurements of hsCRP can’t capture variability at the low end.
Im 24 and mine was 14 lol.
Same question to you as Alex, was this immediately after a rapamycin dose or a fast?
No, it was the day right after I binged on 2500 calories of almonds. I did try to fast on the day before I collected the CRP measurement
Nope, I was not on rapamycin at the time and mine was done after a 12 hour fast from eating dinner the day before.
I doubt that these phenotypic age calculators are very accurate for the very young or the very old.
I am 25 - and from 9 to 12 years less than chronological age (13 to 16) - before starting Rapamycin - but I was taking lithium, NAC and glycine before
1 test: 11 years younger
2 test: 9 years younger (CRP was a little higher than usually but still very low)
3 test: 12 years younger
But I wouldn’t put too much effort into these tests - as long as they are in the normal range.
They don’t measure things that are more related to aging - like somatic mutations, epigenetics, lipofuscin accumulation, etc
But even then: people with progeria have the same epigenetic age as normal people and they still die at 15 years old - so these types of tests don’t tell the whole truth
Most epigenetic age tests require chronological age.
The idea is to have an assessment of biological age. So far people can only do that to a partial extent. Work continues to assess biological age with a reduced effect of chronological age.
I would think that specific blood tests would be of much more value than any of the “age” tests. The obvious question is which blood tests are of greatest value. And are non blood tests of value? Blood pressure, BMI etc.
In reference to the Levine clock, does anyone understand how alk phos is used? That is a test that is high in healthy children, adults with bone disease and liver disease. So a higher number is bad or good?