In the supplementary documents table S5 seems to indicate that there were 5 placebo subjects and 4 rapamycin subjects which makes getting statistically reliable results hard.
It is also not clear whether their 1mg of rapamycin was compounded or not as they have a placebo.
In “methods” they don’t say how many subjects there were.
A probably with WBC is that it can vary for a number of reasons and actually in S5b they seem to mainly go up for placebo and rapamycin.
They do say “While participant numbers in the rapamycin in vivo study are low, the changes in DNA damage and senescence markers is significant.”
I am not persuaded by this paper.
That is not to say it is wrong, however.
Reading it a bit more the rapamycin levels are interesting in the three subjects who took it.
Sadly they don’t give the values but they are approximately 1.5, 2.75 and 5.5 ng/ml.
I wonder if Rapa dosage related to human weight? Given the fact men are often bigger than women, and yellow race people are often smaller than white and black race people.
I’m a male(35 years old) from Asia, weigh 60kg, I take 6mg per week for 1 year. I often suffer from dry lips.
My father(63 years old) weighs 55kg, he take 6mg/week for 1 year, he often suffers from skin allergic dermatitis, now adjust to 4mg/week.
My mother(62 years old) weighs 50kg, she takes 4mg/week for 1 year. She feel fine for now.
At first you must understand causation to correlation. Taking rapamycin may happen at the same time with the skin issues (correlation) but not the cause of the skin issues (causation)
When I called out thunder! at the same time when the thunder strikes, it doesn’t mean my call leading to thunder.
I am from Taiwan (172cm height & 68kg weight) and I takes 24 mg to 36mg of Zydus sirolimus weekly or biweekly, no side effect at all.
That’s quite high for the amount of Rapamycin you are taking. Have you done a blood test for rapamycin or worn a CGM. Are you sure you are actually taking Rapamycin? (who do you buy it from?)
I take a high dose and I have tracked the effects (and posted them on this forum).
I have the same doubt of fake sirolimus before, but it looks exactly the same to others and the supplier is listed as trusted one here. (From India)
However, my hba1c is high, 5.7 to 6 in the past year, LDL also high around 110 to 170. Nevertheless I consider them as necessary price for rapamycin.
Since I also take NAC (2-3g) + Glycine (4-6g) daily, potentially cancelled out the effects of sirolimus, however, people here don’t think it’s a problem…
Its the inhibition of cell division that I think would keep your WBC lower. Mine is normally low and goes lower when I am on rapamycin (I take it less frequently than every 6 weeks, but I take a really high dose).
If your HbA1c has gone up to those figures you can assume that it is rapamycin. My view personally is that having extra autophagy every so often is the issue. I am particularly concerned to avoid inhibiting mtTOR all of the time.
It may be that your WBC would be even higher without rapamycin.
5.7 actually near the lower end of normal range ( 4-11), so I often wear N95 in public place to avoid infection.
Regarding hba1c, it’s the value even I also take metformin 2-4g and Forxiga 10 mg daily.
I am 56 years old now and around 16% body fat. Regular fasting 2-3 days, up to 7 days, exercise regularly, highly diversified diet leaning more on Keto, almost no starch…
I’m around 103 pounds and was taking 6mg weekly simply because that is what my doc wrote the rx for.
Someone here kindly suggested I get labs done because most women don’t take 6mg, and due to my size, that could potentially too much for me…
Well, shockingly, the labs showed I wasn’t taking ENOUGH!! I’m now on 8mg.
I have ZERO idea of what I’m talking about so grain of salt, but my guess has been that weight is often a factor, but maybe your gut quality is also in play (I guessed this because I did the ZOE test that showed my gut microbiome is much worse than most
I get sirolimus from CVS (no idea who manufactures it but CVS is one of the biggest US pharmacies)
I just take it at some point during the day when I remember… no gf juice, no shot of EVO etc. …. I don’t necessarily have an empty stomach because I eat a lot during day, but I don’t usually take anything with a meal (not on purpose)
Thanks and that makes sense. For me, my labs show the 8mg is the sweet spot, and because I get it soooo cheaply and take it all in one gulp, I’d rather take 8 pills instead of fewer and have to manage when/how I take it. I can’t eat too much fatty food, so I just wanna have the yummy food when I decide to have it and not have to force it.
My husband takes the same exact stuff and his sweet spot was 6mg… although the side effects (fever) are too much for him at 6mg, so he now takes 4mg
