Yeah, I’ll be traveling a lot more too in a decade, so maybe we can all meet up Down Under.
The great thing about Rapamycin is that it (probably) gives us an extra healthy decade where we can truly live life unfettered!
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A healthy decade… nah…I am in for 2 decades minimum… 20 extra healthy years.
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I just started Rapamycin at 2 mg with Ageless Rx. 1x per week, gradually increasing to 6 mg/week. I aerobic exercise nearly every day and weight workouts Tuesday, Wednesday and Friday or Saturday. I’m thinking it’s probably best to take the Rapamycin away from when I work out, so I’m thinking Sunday would be best? Or should I drop the Friday / Saturday work out? (I’d rather not) This first week I’m noticing increased energy, but I don’t know if that is a possible side effect? I also increased my Bcomplex vitamin frequency recently, so that could be why.
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Yes, Sunday on your schedule seems reasonable. I also typically take it on a non-workout or light workout day.
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Thankyou! I will try to stick to Friday for my second workout, so I can use Saturday as anabolic.
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is that 6mg all at once, once a week? or 1mg for 6 days?
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Correct… 3 pills… each is 2 mg of Zydus.
Every 7 days.
I take 6 mg rapamycin/zydus once a week.
Ohhh my rapamycin arrive. I might start 3mg a week and see how that goes.
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I found starting at just 1 mg per week and slowly increasing worked well for me, at minimizing side effects.
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Whoops. I’ll see how I go with 3mg. Maybe I lower it to 2mg next week if I get some side effects.
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Does anyone know if everolimus is a more selective inhibitor of mtorc1 than mtorc2 compared to rapamycin?
Ive read that daily sirolimus or everolimus does not fully 100% shut down mtorc1, but does everolimus decrease mTOR more than rapamycin (on an equivalent dose basis, whatever that may be)
I’ve not researched this… for what its worth (perhaps a reasonable starting point for your research) - here is the ChatGPT response:
Hi All, my first post… I am new to rapamycin forum group. I plan to start (in Jnauary 2026, after the xmas and New Year festivities) at 1mg per week, and hopefully build up to 6mg. I have read many of you are taking larger doses. But how do you take the 1mg tablets? Do you take them one at a time ? ie take one, drink water, take another, drink water etc until you have reached your weekly dose? Or do you spread the tablet taking over a period of time, maybe over an hour or 2?
Apologies, if this has been asked before
regards
Sapper
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Welcome!!! How exciting for you!
I assume everyone does what I do which is taking them all at once.
I even take all 8 pills in one gulp, not that I recommend that!!! Don’t try this at home!
A helpful hint that I learned here…once you get to your 6mg dose, if you are in the US, you can get a $25 sirolimus test (at gethealthspan.com) to see if that dose is optimal for you. I was on it for almost a year and discovered 6mg was not enough for me. For others, it’s too much. On dosing day, make sure you are not consuming things that will magnify your dose, unless it’s on purpose, like grapefruit or pomegranate juice
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I take mine with some liquid. I cannot take them at the same swallow because there are too many, but I wash them down with something or other. Normally not alcoholic, however.
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Those are rookie numbers, Beth. I’ve swallowed 20 pills total in one gulp before (I don’t recommend anyone copy this though).
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Exactly… my supplements… all at once with milk at bedtime… easily 15 pills… multiple of boron… lithium… lecithin… lol.
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HA, I did not say that was my max, now did I 
My epitaph will read:
Died while choking on too many longevity supplements
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Thank you all for your wonderful advice and anecdotes.
My current thinking (prone to change with more education) is that I will build up to 6mg or 8mg if I can tolerate it - once a week, and cycle for eight weeks, followed by a four week break.
I am still doing further reading and research, but I am very eager to start on rapamycin in January 2026
Sapper
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