What is the maximum safe daily dose of metformin?

I think Sinclair (or his dad) uses 1500-2000mg. I’ve recently upped my dose to 2000mg/day.

I’ve avoided it recently, mostly due the interaction issues it has with exercise. Looking forward to more research that explores this. I do sometimes take lower dose berberine (~250 - 500mg) on days when I’ve not exercised, or if I’ve eaten too much carbs.

Yes - I also have moved away from metformin for this reason:

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