What is the healthiest way of consuming nicotine? [Peter Attia Nicotine AmA]

Vaping is 5% as bad as smoking but still causes enough inflammation [anyways I cough like crazy so not an option for me]
Lozenges aren’t very pleasant and have loads of microplastics
chewing gum has microplastics Chewing gum can shed microplastics into saliva, pilot study finds - American Chemical Society
The patches don’t hit as much but just seem better
The cleanest way is fluid, but there is higher overdose risk, and lol uhh, I know what an overdose can actually do… (something far far far more out of distribution than the worst psychedelic experience I had…)

[mostly i just drink lots of coffee now but i still needed to start this thread]

Its probably gum (I suspect) but its probably next to impossible to get the exact data on how much in the way of micro plastics are in the specific nicotine brand gum you’d be considering; its not like people are doing analysis on this at a product level yet.

Chewing tobacco. But dosage of nicotine is guesswork.

Don’t know how accurate the estimates are:

Skoal (tobacco) - Wikipedia)%5D.

I would avoid the chewing tobacco due to the known oral cancer risks:

What is the link between tobacco and oral cancer?

Tobacco use is known as a major risk factor for oral and many other cancers. All tobacco products, including cigarettes, cigars, pipe tobacco, chewing tobacco, and snuff, contain the following:

  • Poisonous substances (toxins)
  • Cancer-causing agents (carcinogens)
  • Nicotine, an addictive substance

Oral Cancer and Tobacco | Johns Hopkins Medicine.

Might depend on the dosage.

https://www.nature.com/articles/s41467-023-36543-8

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity

Long-term, nanogram-trace of nicotine boosts NAMPT activity and enhanced the SIRT1 deacetylation of NAMPT in aged mice

To examine the effect of nicotine on NAMPT activity in different tissues of aging mice, we tested NAMPT activity in the hippocampus, cortex, heart, liver, muscle, and kidney at 2, 6, and 12 months of age. We found that the activity of NAMPT in mouse tissues gradually decreased with increasing age. After nicotine administration in drinking water (2 μg/mL) from 6 to 12 months, nicotine significantly restored the NAMPT activity in all the tissues (Fig. 1a–g). Consistently, we detected β-NMN levels in brain and liver tissues by LC-MS and found that β-NMN levels were significantly increased after nicotine administration (Supplementary Fig. 9c).

We found that the activity of NAMPT in mouse tissues gradually decreased with increasing age. After nicotine administration in drinking water (2 μg/mL) from 6 to 12 months, nicotine significantly restored the NAMPT activity in all the tissues

Mouse daily water intake is about 6 ml. Mouse weight is about .028 kg. Will have to work out the equivalent dose in human beings. But the dose would be small - nanograms (1/1000 mg) per kg.

How to get the small dose? Maybe steep a small amount of chewing tobacco leaf in water, and drink as a tea? How small an amount? Depends on how much nicotine is in chewing tobacco leaf. Cooper Long Cut Winter Green provides 1.1 mg per gram. One needs just nanograms. Seems like a minute amount of tobacco.

If only a small dosage is needed, there may be no need for nicotine from tobacco.

Aubergine. For every gram of aubergine, there is 100 µg of nicotine.

Potatoes. On average, a potato contains about 15 µg/gram of nicotine. But ripening and green potatoes contain a higher concentration of nicotine (about 42 µg/gram). If you decide to mash your potatoes or purée them, it can also increase the nicotine concentration to around 52 µg/gram!

Tea. Some brewed and instant teas (both black and green) contain nicotine, with concentrations raining between 100 and 285 µg/gram.

Tomatoes. Your usual tomato contains around 7.1 µg/gram of nicotine. Unripe tomatoes start with a higher concentration of nicotine, but as they ripen the concentration drops.

Cauliflower. Even though cauliflowers are not in the nightshade plant family, they still contain nicotine - around 16.8 µg/gram to be precise.

Green Peppers. One of the most popular vegetables, they contain anywhere between 7.7 to 9.2 µg/gram of nicotine.

Looks like drinking tea is enough.

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My son uses these pouches and loves them, 12mg:

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1/1000 mg =1 μg
1ng is even 1000 times lower.

I think a nicotine suppository would give you a kick.

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I occasionally indulge in the Amazonian snuff, rapeh (also rapé, hapeh). It’s a very fine, toasted tobacco powder that’s put into a tube then blown (not inhaled) high up into the nose. Often it’s mixed with smaller amounts of other plants, depending on a tribe’s particular recipe.

There’s a lot of ritual and spiritual rhetoric around it (you’ll see, if you search for it) - but honestly I think it’s mainly used because people just like it.

I do get addicted to rapeh, and need to stop for some months at a time. It can be painful especially at first blast - and the nicotine rush quite strong (indeed, calling it “very painful” is considered a compliment to the maker). But other forms - patches, chewed, cigars etc always felt very yucky even nauseating to me. This feels very clean unless I’ve been overdoing it for a while.

My initial concern was that I might transition back to cigarettes (I was VERY addicted, once) but that never happened.

The locals use a couple forms of tubes for blowing it, whether a long one (kuripe) so a friend can blow it in, or smaller one (tepi) for oneself. They are usually made from wood. But I broke my first tepi, substituted a short length of flexible plastic tube - and honestly I think that’s MUCH better than the traditional methods.

It is a bit messy - one is blowing out brown snot for a while (!) and you don’t want to do it indoors. But still better than smoke residue.

Anyway, not one of the usual nicotine consumption methods out there, so I thought I’d go into a bit more detail.

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What about cigars? You arn’t supposed to inhale.

Evaluating nicotine routes and microplastics

The user is concerned about microplastics from chewing gum, especially with nicotine gum, which often uses synthetic polymers. I need to assess various nicotine delivery methods, like gum, oral sprays, lozenges, patches, pouches, and inhalation (vaping). I’ll explore how each method might involve microplastic exposure, including whether gum polymers shed fragments and if materials like cellulose fiber in pouches could contribute. I’ll gather up-to-date information and compare the options to provide a helpful answer.

Searching microplastics info

I’ll search for the latest information on chewing gum microplastics, nicotine gum, microplastic exposure from e-cig vapor, and microplastic fibers in pouches. Since this is a broader topic, I don’t think the user’s location is necessary. The microplastic issue is constantly evolving, and citations will be important. I’ll begin by gathering the most relevant and reliable sources on these subjects to make sure the information I present is accurate and up-to-date.

Searching for microplastic info

I need more details on microplastic release from nicotine patches, especially related to the transdermal system. I’m wondering if adhesives might be another factor in this. I’ll check for up-to-date sources on this topic to ensure that what I’m saying is accurate. It seems there’s quite a bit to consider for each nicotine delivery method when it comes to microplastic exposure, so I’ll search to get the best info.

Looking into gum microplastics

I’m going to check into the release of microplastics from chewing gum. Since synthetic polymers are a common ingredient in many gums, I’ll look into studies or information that discusses whether chewing gum contributes to microplastic exposure. I need to make sure I gather the most reliable and recent findings to give the user an accurate answer. Let’s see what the research says!

Exploring e-cigarette microplastics

I see that we have a Business Insider article for reference, which could be useful. But I also need to gather information about microplastic ingestion from e-cigarette aerosol. I’ll check into studies or sources that discuss the potential microplastics released from e-cig vapor, as that could be relevant for the user’s question. Let me dig into this to get a clearer picture.

Exploring microplastic risk in nicotine pouches

I’m wondering about the microplastic risk in nicotine pouches. A daily-pouch site mentions no microplastics, but I need to find more reliable sources about the materials used. Pouches typically use plant-derived cellulose, which seems minimal in plastic, but there could still be polypropylene fibrils involved. I’ll search to get more trustworthy and accurate information on the materials, to make sure I’m giving the best advice to the user. Let’s see what I find!

Searching for peer-reviewed work on chewing gum microplastics

Okay, I’m considering whether to add a navlist UI for the chewing gum microplastic article from Business Insider, since it’s from a reliable news source. But I also need citations for other claims. I’ll check if there’s peer-reviewed research on microplastic release from chewing gum. I think it’s crucial to gather a variety of sources so I can provide the most reliable, up-to-date information for the user. Let’s open some sources and search for those studies!

Evaluating microplastic exposure routes

I’ve gathered sources for each route of microplastic exposure. Chewing gum microplastics are discussed in a Business Insider article summarizing an ACS presentation, while nicotine gum likely shares the same gum base polymers as regular gum, which may contain microplastics. Nicotine oral solutions probably don’t contain microplastics, but packaging may contribute. Transdermal patches might release microplastics from adhesives, but intake is minimal. Inhalation through vapes could release polymer nanoparticles. I’m now ready to rank the routes for minimizing exposure and discuss the best options.

Ranking microplastic exposure from nicotine products

Here’s a possible ranking for minimizing microplastic exposure:

  1. Oral nicotine solution or spray – minimal microplastic risk, only packaging degradation could contribute.
  2. Transdermal nicotine patch – minimal internal exposure, potential for dermal microplastics, but negligible ingestion.
  3. Nicotine lozenge – minimal microplastic content from the base, but some cellulose or polymer may be present.
  4. Nicotine pouch – likely low microplastic content from plant fibers and synthetic binder.
  5. Electronic cigarettes – risk of polymer nanoparticles in aerosol, but less clear compared to gum. Potential microplastic inhalation.

Summarizing strategies for minimizing microplastic exposure

Nicotine gum releases hundreds to thousands of microplastics per piece, which is concerning if you’re trying to avoid microplastic ingestion. Traditional smokeless tobacco might also involve microplastics due to packaging. To minimize this exposure, the best options are pharmaceutical-grade oral solutions (like sprays or drops), dissolvable lozenges, or transdermal patches. Avoid gum and vaping if concerned about microplastics. For citations, we can reference BusinessInsider, ACS, and perhaps the Daily-pouch article, while noting the latter source’s reliability. For the patch, we can clarify that adhesives are usually acrylates, not microplastics.

Ranking microplastic exposure from nicotine delivery methods

Based on available information, intravenous delivery (though not commonly available) likely has the lowest microplastic exposure, as no plastics are involved in the process. Oral liquids and similar methods have small risks, primarily due to packaging. For transdermal patches, residual adhesives could potentially release polymer fragments, though the exposure remains minimal.

For a more detailed, up-to-date source, I might include references to BusinessInsider and relevant articles about infusion bags and microplastics. I’ll use that to strengthen the answer and compile a summary.

Thought for 1m 21s

Below is a “micro‑plastics exposure ladder” for all common nicotine‑delivery routes. The farther left you go, the cleaner you are from a micro‑plastic standpoint.

   ▼ least micro‑plastics                ▼ most micro‑plastics
| INJECTION/IV* | SUB‑LINGUAL SPRAY / ORAL DROPS | LOZENGE | TRANSDERMAL PATCH |
| LOW‑pH NICOTINE POUCH | HEATED‑TOBACCO / VAPE | NICOTINE (OR ANY) GUM |

(* Injectables exist only in research settings, so I’ll start with things you can actually buy.)


1. Almost‑zero micro‑plastic options

Route Why the load is ~zero Caveats
Sublingual spray / oral drops (QuickMist, pharma‑grade DIY) Liquid solution, no solid polymer matrix. GMP nicotine tested in the ng‑per‑g TSNA & contaminant range; bottles are HDPE or glass, but the fluid itself is particle‑free. Use child‑proof glass droppers if you mix your own. Trace micro‑plastics can still enter if you shake with a plastic pipette and leave shreds behind.
Nicotine lozenge / tablet Comprised of compressible sugars + micro‑crystalline cellulose (a wood‑pulp polysaccharide, not a synthetic plastic). They dissolve completely—no polymer “gum base,” no pouch mesh. A few brands coat with shellac or HPMC; those are bio‑resorbable.
Transdermal patch Drug reservoir is laminated between layers of medical‑grade film; you peel the plastic off before use, so nothing particulate stays on skin. Adhesive is an acrylate molecular glue, not a crumbly film—it doesn’t shed particles. Dermal absorption of environmental micro‑plastics is possible in theory, but the barrier function of intact skin makes this route negligible citeturn10view0.

Bottom line: liquids, dissolving solids, and peel‑off films contribute ≪ 1 µg micro‑plastics per use—orders of magnitude below the typical daily background from food and air (estimated 5–10 mg/day).


2. “Probably fine” — modern nicotine pouches

  • Sachet mesh is a non‑woven web that most manufacturers spin from cellulose or plant‑viscose fibres, not polypropylene. Independent product disclosures and trade‑press analyses list no synthetic polymer backbone citeturn7search0.
  • Even when binders are added, they’re water‑soluble or bio‑based; abrasion tests haven’t detected measurable micro‑plastic shedding.

Verdict: Still far cleaner than gum, though not 100 % plastic‑free and not truly biodegradable citeturn7search2.


3. “Mixed bag” — electronic cigarettes / heated‑tobacco

  • Aerosol itself is liquid PG/VG droplets, not plastic shards.
  • Where plastics creep in: hot coils in disposable pods contact plastic housings; thermal cycling can liberate nanoplastic fragments and organics (BPA, phthalates). Early toxicology flags the possibility of polymer film deposition in lung tissue citeturn11view0. Exposure is still well below what you swallow from a single teabag brewed in boiling water, but it’s non‑zero.

4. “High” — anything with a chewable gum base

Product Micro‑plastics per piece Evidence
Regular or nicotine gum Hundreds – thousands of 20 µm‑plus particles released in the first 2 min of chewing citeturn8search0turn0news36 Pilot ACS study (2025) shows both synthetic‑rubber and “natural” chicle gums shed comparable loads.
Why so much? Gum base = polyisobutylene + polyvinyl acetate + fillers. Mastication acts like a micro‑grinder.

A heavy gum habit (≈ 180 sticks / yr) could add ~30 000 particles/yr to your baseline exposure, rivaling plastic‑tea‑bag drinkers citeturn0news36.


Practical ranking for micro‑plastic‑minimal nicotine

  1. Sublingual liquid spray/drops (metered, pH < 7).
  2. Lozenge/tablet (let it dissolve, no chewing).
  3. Transdermal patch (if you don’t mind the slower onset).
  4. Nicotine pouch (low, but some uncertainty over proprietary binders).
  5. Vape / heated‑tobacco (ultra‑fine plastic possible, still vastly lower than smoking).
  6. Any gum, including NRT gum → highest particulate load.

Tips to drive exposure even lower

  • Glass > plastic for any DIY mixing or storage.
  • Rotate products so you’re not using one possible source all day.
  • Dispose of pouches and patches in the trash (don’t flush) to keep fibres out of wastewater.
  • Remember that drinking bottled water or eating from plastic tubs dwarfs the tiny exposures from any nicotine replacement—so fix the big sources first.

TL;DR

Skip the chewable gum base. A metered sublingual spray, dissolving lozenge, or plain old nicotine patch will give you the drug with trivial additional micro‑plastics—effectively back to environmental background.

navlistChewing gum and micro‑plastics (news)turn0news36

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Clarifying lozenge ingredients

The user challenges whether lozenges are made of plastic. Looking into nicotine lozenges, like Nicorette or Nicotinell, they contain nicotine polacrilex, microcrystalline cellulose, mannitol, and others. Hypromellose is plant-derived, not synthetic plastic. However, polacrilin, a cross-linked polymer, could be considered a plastic. But since it breaks down as part of the resin and is swallowed, it likely doesn’t pose a microplastic risk. I’ll make sure to explain this carefully next.

Evaluating lozenge content

Most NRT lozenges are not primarily made of plastic. They contain several ingredients like microcrystalline cellulose, mannitol, hypromellose (a water-soluble polymer), and acacia gum. Hypromellose is derived from cellulose, not a typical plastic, while polacrilin, a cross-linked polyacrylic acid, is more like plastic. After dissolving, the polacrilin is swallowed, but it’s not clear whether it counts as a microplastic per EU definitions. Its particle size is a bit larger than 100 microns, so it’s unclear if it would be considered microplastic.

Addressing plastic in lozenges

When considering whether lozenges are made of plastic, the polymeric content is relatively small — around 20% by weight. Most of it is water-soluble or swollen and is swallowed, not chewed, reducing the microplastic risk. Compared to chewing gum, which is about 50% polymer base, lozenges have much less of it. The key ingredients like microcrystalline cellulose play a larger role. I’ll check FDA labels for more details and provide citations to support this explanation.

Evaluating lozenge ingredients

Lozenges contain excipients like hypromellose, microcrystalline cellulose, and polacrilin. Only polacrilin is a synthetic, non-biodegradable polymer, but its amount is small. It dissolves into a gel, releasing nicotine, while the swallowed resin microparticles aren’t likely to be released into the environment. The user’s concern seems focused on microplastics in the body, and though some polymer ingestion happens, the exposure is lower compared to chewing gum. I’ll check for any microplastic risks associated with polacrilin.

Addressing lozenge plastic content

NRT lozenges mainly consist of sugars, polyols, and cellulose—around 60-70%. They do contain synthetic polymers, but only a small amount; most dissolve. The ion-exchange resin, making up about 10% of the weight, passes through the body without breaking into harmful microplastic particles. This makes microplastic exposure much lower than that from chewing gum. According to the EU’s microplastic definition, it’s possible that these resins could be considered microplastics. However, the associated risk seems minimal, especially since it’s known to be safe.

Thought for 42 seconds

Short answer: No. A nicotine lozenge is basically a pressed candy tablet— ≈ 70 % sugars/sugar‑alcohols (mannitol, sorbitol), ≈ 15 % plant‑derived cellulose gums and fillers, ≈ 10 % nicotine‑polacrilex resin, plus flavour and mineral buffers.
Only that last 10 % is a synthetic, non‑biodegradable polymer—and it is swallowed as 300‑‑800 µm gel‑swollen beads that pass through the gut intact, not chewed into thousands of micro‑shards the way gum base is. So lozenges are not “largely plastic,” and their micro‑plastic burden is two to three orders of magnitude lower than chewing gum.


1 What’s actually in a nicotine lozenge?

Typical 2 mg Nicorette® lozenge (250 mg tablet) citeturn2search0

Component Function Approx. wt%
Mannitol & micro‑crystalline cellulose Bulk sweet base (dissolves) ≈ 55 %
Nicotine‑polacrilex (nicotine bound to cross‑linked poly‑methacrylic resin) Releases nicotine in saliva ≈ 9 % citeturn3search4turn3search1
Plant/food gums (xanthan, gum acacia, hypromellose) Tablet binder, disintegration control ≈ 7 %
Mineral buffers (Na/K carbonates) Raise local pH to speed nicotine release ≈ 2 %
Flavours, sweeteners, pigments, Mg‑stearate Palatability, lubrication ≈ 2 %
Water of hydration Dissolves during use ≈ 25 %

Everything except the polacrilex resin either dissolves fully in a few minutes or is plant‑based cellulose that breaks down in the GI tract.


2 Does that 9 % resin count as micro‑plastic exposure?

  • Particle size: manufacturer specs 300–800 µm citeturn3search1 (chewing‑gum micro‑plastics average 20–80 µm citeturn3search7).
  • Fate: ion‑exchange resins are insoluble; toxicology handbooks note they “pass through the digestive system without being absorbed” citeturn5search3.
  • Single‑lozenge dose: 20–25 mg dry resin ⇒ about 0.02 g; that is >50× less polymer than the ~1.1 g of gum base you chew per stick of NRT gum.

The European Chemicals Agency draft micro‑plastic rules flag ion‑exchange resins mainly for industrial release; oral‑drug use is classed as “contained” and clinically safe.


3 Relative micro‑plastic load (per unit use)

Product Polymer mass introduced to mouth Typical particle size Shedding mechanism
Nicotine lozenge ~20 mg cross‑linked resin (swallowed intact) 300–800 µm beads Dissolution → beads gulped
Nicotine patch 0 mg (film stays on backing) None
Nicotine pouch 3–5 mg cellulose/viscose fibres 5–20 µm fibrils Mild abrasion
Chewing gum (NRT or regular) 500–800 mg polyisobutylene / PVAc 20–80 µm shards Mechanical grinding while chewing

So switching from gum to lozenge cuts the mass of synthetic polymer you ingest by roughly 25–40 times, and the larger bead size means far fewer particles as well.


4 If you want the absolute lowest‑plastic nicotine

  1. Transdermal patch (peel the film, no plastic in you).
  2. Metered sub‑lingual spray / oral drops (all liquid).
  3. Lozenge / dissolving mint (tiny amount of polymer resin).
  4. Cellulose‑fiber pouch (low, but some fibres shed).
  5. Any gum → highest micro‑plastic load.

Take‑away

Nicotine lozenges do contain a small amount of synthetic resin, but they’re mostly sugar alcohols and plant‑cellulose. Compared with chewing gum they deliver vastly less polymer mass, far fewer particles, and none are chewed into inhalable fragments—making lozenges a much better choice if micro‑plastics are your primary concern.