This is across Horvath. It looks like differences in +/- 10 years are not too uncommon, but a few outliers in the low range. This is only for ppl 40 years and older (I expect more outliers in older age groups). A 50 year old has the HorvathAge of a 20 year old!!! I want to know who that is… but I suspect it may not be too diagnostic… Even Verdin’s recent epigenetic clock he presented at the aging conference has almost zero overlap with most of the other epigenetic clocks
These sites and the genes close to/ within which they are located are listed in Table 1, ranked from the one showing the largest inter-personal variation (largest average SD of all chronological age groups) to the smallest. The two most dominant variable sites are related to secretagogin (SCGN) and malin [NHL Repeat Containing E3 Ubiquitin Protein Ligase 1 (NHLRC1)]. Eight probes out of the 9 most variable probes selected were found to be independent of the population size (≥ 80% confidence). Specifically, secretagogin and malin were selected in 100% and 98% of the statistical simulations, respectively, indicating independence of the population size (Additional file 1: Table S4).
For example, one study analyzed the DNA methylation levels of peripheral blood mononuclear cells (a type of white blood cell) from semi-supercentenarians and their offspring. The investigators found that the average epigenetic age of the semi-supercentenarians was nearly nine years younger than their chronological age. The epigenetic age of their offspring was approximately five years younger than that of their age-matched controls.
I think this highlights something about epigenetic age that is difficult to get a sense for. That Supercentinarian 114 year old might be 9 years younger in an epigenetic clock, but almost nobody makes it to 105 either.
It’s not as if everyone is living until their epigenetic age hits exactly 85 or something. There is a decent chunk of what makes longevity that is not being captured in the epigenetic clock.
It definitely is capturing something important, but it isn’t the entire picture.
He has -10 years (at his advanced age of 70). This is near-outlier level. FWIW, high deltas are more common at higher ages (more time for the environment to work out differences in aging rates between ppl + epigenetic aging naturally decelerates at higher ages)
But 30 year-olds with epigenetic ages of 50!!! I know one… This… demands… further investigation
Ryan says “make sure biological age is ~7 years younger” to make yourself 50% less likely to die than someone your age [8 years is mortality rate doubling time in humans…]. 1SD in epigenetic aging is roughly 6-8 years across the clocks…
It’s interesting that ppl epigenetically 8 years older have the mortality doubling time of those 8 years older
So a 100 year old has roughly the same mortality rate as one 24 years older who is roughly 24 DNAm years younger which kind of matches the outer upper end of human mortality.
I figure that maybe the outer edge is roughly 24 years or more than 3SDs (1SD is like 6 to 8 years on the clocks). But this really only shows up at older ages cuz there’s more time for the environment to work out differences in ppl. Superagers probably have an advantage of 15 to 25 years, or like 2 to 3 mortality doubling times.
The star trek 90 year old (William shatner) comes off as roughly 25 years younger
Lure hsu can come off as 25 years younger but does not appear teenage young