Sure, me too, but how? Exercise is available now. 
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Good point, thanks …
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Well i will take those added years and another 40-50%. Aiming to live long enough for more great discoveries then rapa, acarbose, astaxanthin etc. But those 3 i belive will at least get me there for many new discoveries + exersize 
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Balanced diet and regular exercise are most important before all the supplements and interventions. Good health can’t be bottled.
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Absolutely the most powerful way to live longer is to have “lucky” genes.
I have seen it too many times with friends and relatives.
Here is a lady that is 92 years old and doesn’t use expensive creams or cosmetics on her face. She has been featured in several tabloids.
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Genes effect on controllable variables can’t be underestimated either, in case anyone missed it, this study showed that every 24 mg/dl increase in apoB above the median decreased chance to live to 90th percentile of lifespan by 60%:
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I think we’re all used to go into nuance and depth, but these sorts of newspaper articles are meant to be superficial summaries. I used to work as a journalist so I have a lot of sympathy. The rule (which I didn’t follow myself) is that if you want to select what goes in give very short interviews.
As for the 17-alpha E, yes, it’s still part of my longevity stack. I’m on all four now: rapamycin, acarbose, empagliflozin and 17-a-E (I also mentioned that, but only two made it in.) I also take a PCSK9i as monotherapy (no statin).
The 17-a-E does clearly increase estradiol and IGF-1 so I’ll take vacations from it same as I take from rapamycin. But currently I feel great. Mondays on non-rapa weeks are my hardest days, with three workouts, and though I feel tired this morning (Tue), it’s a really good tired. Five years ago, before all the fine tuning, there’s no way I could have handled this sort of training volume. All my bloodwork, sexual function, everything is excellent. (I only mention sexual function because of the estradiol.) How’s all with you?
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What’s causing reduction in movement speed (or movement in general) with aging? Is it fatigue, reduction in cardiovascular conditioning, or is it related to brain, for example dopamine?
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I would like to know the answer to this also. No amount of resistance or aerobic exercise prevents this. It may slow it down a little. I think the answer to this question is key. If we could prevent this it would make a world of difference.
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There are two separate big problems. One is the difficulty in building muscle (sarcopenia), the second is the weakening of bones (osteoporosis). There are also balance and cognition issues.
Osteoporosis occurs because osteoblasts fail to be created whereas osteoclasts continue to be created. Hence the bones are broken down by osteoclasts as normal, but not rebuilt by the osteoblasts. This is a differentiation issue.
With muscle cells they stop producing certain proteins.
Both of these are gene expression issues.
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I’ve read on multiple occasions that life style will get you to 90 , but good genes are the key to getting to 100+. The article you posted said pretty much the same.
I’m hoping that intervening with rapamycin will get us over the hump regardless of our genes. I don’t think that lifestyle interventions will do it.
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But the choices you make in life are also highly influenced by genetics.
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Ah, the old: Do we have free will or not?
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Regarding bone health and exercise, I think I have a real-world example of the relationship.
I recently had a conversation with a UCSD bone person. We discussed the results of a DXA scan I had a couple of months ago.
One of the findings was the following:
Whereas my bone mineral density T-score (results relative to a 20yo female) for spine is -2.8, and hips -1.8, trabecular bone score is ‘only’ -0.6.
What is trabecular bone?
I think the last sentence is key. While I might meet the criteria for an osteoporosis diagnosis (not great), the internal structures (trabecula) are in far better shape than one might guess (highly discordant). This I put down to humping a 10-12kg backpack around the neighborhood for training, and the thousands of miles I hike in the preceding decade and a half. Had I not been doing this, I’d be in a far riskier situation w/r/t to falls and whatnot.
Anyway, now I think I understand what a reference to ‘bone quality’ actually means.
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Pretty soon, we’ll probably have ways to stop muscle loss in old folks. But honestly, I think it’ll be tougher to clean out the arteries after years of chowing down on a diet full of animal protein and loads of unsaturated fats.
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Muscle loss and loss of balance are serious issues. A good friend of mine passed away last Sunday because he fell and hit his head. While he was in the hospital having surgery he contracted COVID and that finished him off. He was in his 80s. He was very active and vibrant until the day of his accident.
If he hadn’t lost his balance, he’d still be alive for probably many years.
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I was diagnosed with osteoporosis over 20 years ago, I’ve never broken a bone and I’ve had some falls that one would figure would result in a fracture. A couple of months ago I stupidly jumped off the top of a 4 foot wall. I tweaked my left knee but I got better in about 3 weeks. I could really have gotten hurt. But the point is I am suspect of the DEXA test, at least for some like myself.
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Lots of people in this thread talking about genetics. This study finds that “the true heritability of human longevity for birth cohorts across the 1800s and early 1900s was well below 10%” - which indicates that environment is a much more significant factor, and the choices you make in food and exercise, among other things, will have a larger influence on your longevity than will genetics.
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Actually, a treatment is right around the corner. It’s just going into clinical trials in the UK.
I’ve been tracking this company for a while. Crossing fingers for positive results. It will be a game changer for millions of people.
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Yes - Cyclarity Therapeutics is very interesting. The company is being incubated at the Buck Institute.
A good podcast with the founder is here:
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