Thank you for sharing. I knew there was a Canadian connection, but not all this rich history.
Without long term RCT trials, mainstream doctors are never going to script an “immunosuppression, transplant, anti-cancer” drug. Really bad optics, massive liability concerns without an FDA backing. No mainstream federal agency is deeming aging a “disease”.
And these trials will NEVER get funded for Rapamycin…off patent, no financial incentive for anyone connected to Pharma. Only a patented Rapalog “might” get a trial funded, but it’s a long way to prove median/total lifespan!!
DNA methylation, pheno-age, or some other intermediate primary end point trials might get realized when critical mass self-hacking AND medical community supports.
At least it looks like we might be starting with dogs…go MK!
Another reason why this drug might be best adopted in Canada - where the legal industry is not so omnipresent as in the US. And, even in the US, you already have many doctors prescribing rapamycin for the past 5 years, with no significant issues…
Yes, I am getting lots of new hair growth. It is slow because the new hairs are coming out of dormant hair follicles. Very fine and thin, but resilient. The new hairs are thickening my front and crown hair.
@RapGuy . @RapAdmin , others!:
Do you have lab results with/without grapefruit?
Do you have lab results with generic pills/ pfizer pills?
What is the concentration we should aim? (The log graph presented at the top of the chat is a real mess). I guess the only useful part is after 24 hrs. Am I right to say that one should expect concentrations of 2ng/mL after 24 hours? (I’m following the line of 3 mg/m2. This because for my weight (72kg) and my height (179cm) gives an approximate superficial area of 1.9m2. Then 3mg/m2 equates to 6mg total for me.
Do you have the raw numbers of that graph for the first 24 hours? As I said, it is useful in the range 0-24hrs.
Many. many thanks! (I’m still looking for a GP that can prescribe me the lab tests in Perth Australia, this is another mess!)
For full transparency, I work at Marek Health.
We offer low-margin self-service blood testing as part of our mission to reduce the barrier of entry to affordable health care.
Our Rapamycin (Sirolimus) serum blood test (LC/MS-MS) via LabCorp is only $59 vs $95 at LEF.
Additionally, the LEF “Chemistry Panel” (Lipids, CBC, CMP) is only $25 at Marek vs $35 at LEF.
Also, Marek Health offers the high sensitivity CRP test for $20 vs $42 at LEF.
And the IGF-1 test for $39 vs $75 at LEF.
If this is against the rules here please delete my post. I stand to gain nothing, I am simply trying to help others get access to the same lab tests at lower costs.
You do not need to pay any consulting fee to access lab tests.
If you want interpretation, coaching, and prescriptions, that is when you would pay a $250 patient exam fee.
Marek Health has two lines of business:
Self-Service Lab Work
Concierge Health Coaching (Guided Optimization)
I’m going to be fully transparent here.
The self-service lab work is not a profit centre for us. It’s goal is to get people access to affordable diagnostic lab work as we believe it’s important. However, it also serves as a free marketing campaign for our brand. We believe if we offer the most affordable, convenient diagnostic lab tests it is inevitable that a huge number of eyes utilize our services. A small percentage of those will read the about marek page, or follow our social media, or read our trustpilot reviews and decide they want help interpreting their lab markers, opimizing their health, improving their longevity, etc and that drives business to our real profit centre – guided optimization.
Hence, the lab test prices you see are not introductory prices or special sales prices. They are simply lab tests with very low margins, mostly to cover overhead.
I noticed Marek offers the new Glutathione test through Labcorp for $59. Other places charge at least twice that. Glynac (NAC + glycine) is reputed to improve glutathione levels. It would be interesting to see if anyone has a measurable increase in glutathione after being on this mix for a while.