What are your homocysteine levels? What have you done to reduce it? Why isn't it part of PhenoAge or aging.ai clocks?

But hard plaque is preferable to soft plaque. Both statins and exercise increase hard plaque.
If it was as simple as the guy from Harvard said, a simple rct where one group gets vitamin B complex + TMG (and omega 3 EPA?) while the other gets placebo should show significant differences in plaque development, calcification score and stroke/heart attack rates.

2.5mg MF, 1g TMG, 1Tbsp sunflower lecithin dropped mine from 11 to 7 in 4 weeks. I’m a compound heterozygote at MTHFR

Does that help with homocysteine?

Powerful

What is MF?

Is there a lot of support for sunflower lecithin in this context?

No, but some arguments I’ve heard say that omega 3 is only useful in combination with vitamin B and TMG.

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Methylfolate. The lecithin is a source of phosphatidylcholine. I get standard doses of the other B vitamins in my multi as they play a role as well but I was on those at baseline before I added the 3 supplements above and got my HMCY to drop. I suspect majority of the effect is from TMG and to a lesser degree the folate.

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