What are you doing for each of the hallmarks of aging?

Thought it would interesting to map various interventions against some of the key Hallmarks of aging. Rapamycin seems to cover a lot of bases. Interested to see what others will add to this list

  1. Genomic instability - methylated b vitamins [Nutrition and genome health - PubMed]

  2. Telomere attrition med diet, exercise, methylfolate, vit d3

  3. . Epigenetic alterations. Rapamycin, spermidine, fish/omega3

  4. Loss of proteostasis. Reduce inflammation with Mediterranean diet, spermidine, berberine, curcumin, and quercetin, regular exercise

  5. Deregulated nutrient sensing IFasting, rapamycin, metformin?

  6. Mitochondrial dysfunction vit d, rapamycin, taurine, exercise, citrate

  7. Cellular senescence rapamycin, metformin, apigenin, and kaempferol

  8. Stem cell exhaustion fastmimicking diet? Rapa?

  9. Altered intercellular communication rapa, exercise, spermidine

  10. Compromised autophagy. I Fasting, rapamycin