Thought it would interesting to map various interventions against some of the key Hallmarks of aging. Rapamycin seems to cover a lot of bases. Interested to see what others will add to this list
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Genomic instability - methylated b vitamins [Nutrition and genome health - PubMed]
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Telomere attrition med diet, exercise, methylfolate, vit d3
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. Epigenetic alterations. Rapamycin, spermidine, fish/omega3
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Loss of proteostasis. Reduce inflammation with Mediterranean diet, spermidine, berberine, curcumin, and quercetin, regular exercise
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Deregulated nutrient sensing IFasting, rapamycin, metformin?
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Mitochondrial dysfunction vit d, rapamycin, taurine, exercise, citrate
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Cellular senescence rapamycin, metformin, apigenin, and kaempferol
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Stem cell exhaustion fastmimicking diet? Rapa?
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Altered intercellular communication rapa, exercise, spermidine
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Compromised autophagy. I Fasting, rapamycin