It has been a while since Vince Giuliano has posted to his blog. For those not familiar with Vince, he is a 93 year old with a broad science background. He does in-depth analysis of longevity related topics. And I find his personal health habits interesting and relevant.
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Thanks for that. I’ve read all of his blogs religiously and consider Vince to be an extremely smart guy and an expert on all things aging. He tends to keep a low profile, avoids hyperbole, and is very evidence based.
Regarding some of his points:
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I agree that loss of epigenetic information and the subsequent loss of beneficial gene expression is a major cause of aging. On the other hand, I’m not as confident that the present day tests are all that reliable.
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I fully agree that chronic inflammation plays a huge role in the process.
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It does seem that 122 is our max age limit at present, but we’re fairly close to overcoming it.
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He mentions rapamycin, but as far as I can tell, he doesn’t take it himself. He doesn’t respond to emails so I’m not certain.
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He mentions metformin as a life extender in the same sentence as rapamycin and I certainly disagree.
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He’s taken numerous supplements over the years. At one count it was about 60 a day. He’s still going strong.
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He makes an interesting point that if you want to be a healthy 200, you must first do the things required to be a healthy 100.
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I’m looking forward to his educational material. I wish that he were a part of this forum.
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Thank you for the reference. Excellent article and it gives me hope to live to 120 yrs at least.
“In particular, I have focused on the importance of controlling chronic inflammation for healthy aging”
Fortunately, I gleaned the importance of chronic inflammation many years ago and started using anti-inflammation supplements such as Boswellia serrata (Frankincense).
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Jeanne Calment made history when she died at the age of 122 in 1997, but a new investigation claims her daughter actually assumed her identity in 1934. Was the World’s Oldest Person Ever Actually Her 99-Year-Old Daughter? Where are we getting the 120?
My great Aunt passed away at 106. I recall; she was a first-generation Sicilian living in the US, my grandfather’s sister; in fact, all his siblings (6 of them) lived well into their late 90s. She lived with her husband, that smoked two packs a day; she was a beautician into her 80s worked with hair dyes and chemicals. Her favorite meal was a burger, fries, and a shake, which she ate daily! Genetics! Can’t imagine if she took Rapa, and had a diet and exercise routine, maybe 120?
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| 1 | Kane Tanaka[4] | F | 2 January 1903 | 19 April 2022 | 119 years, 107 days | Fukuoka | Fukuoka |
|---|---|---|---|---|---|---|---|
| 2 | Nabi Tajima[4] | F | 4 August 1900 | 21 April 2018 | 117 years, 260 days | Kagoshima | Kagoshima |
| 3 | Chiyo Miyako[4] | F | 2 May 1901 | 22 July 2018 | 117 years, 81 days | Wakayama | Kanagawa |
| 4 | Misao Okawa[4] | F | 5 March 1898 | 1 April 2015 | 117 years, 27 days | ĹŚsaka | ĹŚsaka |
| 5 | Tane Ikai[5] | F | 18 January 1879 | 12 July 1995 | 116 years, 175 days | Aichi | Aichi |
Full list below; verified by the Gerontology Research Group, based in LA, CA.
List of Japanese supercentenarians - Wikipedia.
Andrei Gudkov also opines that the cliff (as he calls it) is 120 years.
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Boswellia is good.
You can keep the myrrh.
Send the gold to me!
Vince has 2 new posts on his Anti-Aging Firewall Blog.. Some interesting facets of what he thinks important for longevity at an older age. A snipit of his intro below. His blog post is good candidate for an ai summary.
This blog entry also outlines a number of interventions and activities that can help fundamentally healthy people have a high likelihood of reaching 100 or so years of age, remaining healthy and functional, cognitively all there, and working and contributing to their families and society. These activities and interventions are the ones that have been are working for me. My 96th birthday was 11-18-2025, and I expect to keep working and contributing until I am at least 100.
Preface and a personal note to 2023 version
In April of this year, I experienced a breakthrough in understanding human aging. This was a key event for me, coming after 15 years of full-time study and writing 600 or so articles on nearly every conceivable facet of the subject. A second key breakthrough was directly derived from this understanding. I had finally articulated a simple set of scientifically grounded interventions, applicable late in life, that can likely extend healthy active human lifespans by 20% to 30%, allowing most people to be healthy and continuing contributors to their family and professional lives until they are 100 or beyond.
To my knowledge, I am the only longevity researcher in my age cohort who is still alive, active, researching, writing, and publishing. I have been pursuing versions of many of the specific longevity interventions suggested in this blog for over 40 years now, improving on them as I learn more. They seem to continue working well. Turning 94 in two months(November 17, 2023), I am now nearly as healthy, functional, and physically active as I was 40 years ago, and perhaps a bit more professionally engaged and intellectually active than ever before. I expect this situation will go on until I am well beyond 100. ”You must have good genes” is not the explanation. Everyone in my family besides my mother died in their 70s. My mother required intensive nursing care starting in her late 80s and died at age 91.
I have none of the known degenerative diseases of advanced aging. I haven’t seen a real doctor for 10 months. I can climb stairs, cook up pasta Bolognese for the whole family, vacuum key areas of the house, do the laundry and wash a sink-full of dishes and load the dishwasher every night. And get in 6-12 hours of longevity research, communications with colleagues and writing every day. Unlike some of my close colleagues, I only monitor a tiny collection of health and aging biomarkers. For the same reason most people in their 30s and 40’s don’t bother with their biomarkers – they don’t have to.
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