Valproic acid - is it pro-longevity or anti-longevity? (it helps open up chromatin, which might make it more damage-prone)

#1

valproic acid opens up chromatin structure (WITHOUT CONTEXT - anything that opens it up presumably makes it more damageable). But with context, it’s SO much more complicated…

pro-longevity (only in C. elegans, need to test in more complex organisms).

1 comment on PubPeer (by: Acontia Elaeoa)

ALSO it’s a neuroplasticity enhancer (reopens critical period learning of absolute pitch - Valproate reopens critical-period learning of absolute pitch - PMC )

(Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences - PMC ).

pro-ROS (in rats):

also potentially relevant reading: https://www.reddit.com/r/Nootropics/comments/5bqrpm/i_figured_out_prl853s_mechanism_of_action/

2 Likes
#2

You know what? I find this super intriguing!

#3

https://genomics.senescence.info/drugs/drug_details.php?compound_name=Valproic%20acid

increases amylase.

May produce encelophathy

Seems to me, best left to the worms.