valproic acid opens up chromatin structure (WITHOUT CONTEXT - anything that opens it up presumably makes it more damageable). But with context, it’s SO much more complicated…
pro-longevity (only in C. elegans, need to test in more complex organisms).
1 comment on PubPeer (by: Acontia Elaeoa)
ALSO it’s a neuroplasticity enhancer (reopens critical period learning of absolute pitch - Valproate reopens critical-period learning of absolute pitch - PMC )
(Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences - PMC ).
pro-ROS (in rats):
also potentially relevant reading: https://www.reddit.com/r/Nootropics/comments/5bqrpm/i_figured_out_prl853s_mechanism_of_action/