Vaccines for longevity

Shingles vaccine may actually slow down dementia, study finds

If these findings are confirmed, “then this would be groundbreaking for dementia,” an expert said.

A common vaccine meant to ward off shingles may be doing something even more extraordinary: protecting the brain.

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Earlier this year, researchers reported that the shingles vaccine cuts the risk of developing dementia by 20 percent over a seven-year period.

A large follow-up study has found that shingles vaccination may protect against risks at different stages of dementia — including for people already diagnosed.

The research, published Tuesday in the journal Cell, found that cognitively healthy people who received the vaccine were less likely to develop mild cognitive impairment, an early symptomatic phase before dementia.

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Crucially, the study suggests that the shingles vaccine — two doses of which are recommended for adults 50 and older or those 19 and older with a weakened immune system — may help people who already have dementia. Those who got the vaccine were almost 30 percent less likely to die of dementia over nine years, suggesting the vaccine may be slowing the progression of the neurodegenerative syndrome.

“It appears to be protective along the spectrum or the trajectory of the disease,” said Anupam Jena, a professor of health care policy at Harvard Medical School and a physician at Massachusetts General Hospital who reviewed the paper.

Read full story: Shingles vaccine may actually slow down dementia, study finds (Washington Post)

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I’m completely sold…

He has just consumed what may be the world’s first vaccine delivered in a beer. It could be the first small sip toward making vaccines more palatable and accessible to people around the world.

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Simplified beer production is on page 15.

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I’m interested in the result. It’s not being done by his lackeys, they got Denmark to do it. They’re not messing with the end point, it’s all cause mortality. They’re doing there because they have the disease bad there. If it works there it will certainly work here. This is backwards from the way things have been done.

This guy acts like he knows how it will come out. Make him put the expected results in writing now and don’t ignore it when he’s wrong. I’ve been farming for 45 years and should know exactly what’s going on yet I’m surprised yearly. With living things you don’t know if you don’t try.

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Interesting if true.

ACM is a telltale sign for infiltration by quacks and lysenkoists. It’s what all of them exclaim for every medical thing there is.

You don’t want to test for ACM, as you’re going to maim and kill a lot of people (here children in Guinea-Bissau) to try and detect it in the process, it’s a pure statistical/mathematical thing that’s terrible. You don’t want to run new experiments when you already have data from other types like randomized trials and epidemiological studies. That’s why ACM studies aren’t done. They say they need to test for ACM because they don’t feel like they like the vaccines and that’s what they can try to justify it, it’s lunacy.

It’s also unethical to do medical experiments like this.

Longevity community need to stay away from these lunatics and their policy-driven research. It’s going to backfire tremendously.

If they’re funding it, after what they’ve done, they are doing it. It’s obviously not something decided by top talent with training in ethics, philosophy, science, etc.

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https://www.reuters.com/business/healthcare-pharmaceuticals/merck-expects-over-5-billion-commercial-opportunity-cidaras-flu-drug-2025-11-17/

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This is amazing news, if it gets fda approval . It seems like it’s not a traditional vaccine, it’s an antiviral drug that works against every flu mutation, by blocking and essential protein in replication.

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You mean a broadly neutralizing antibody for a conserved target?

I’m planning to get vaccinated against smallpox this year. It’s a vanishingly small tail risk, but why not? If smallpox somehow did get out in the wild again, I’d be damn happy I’d had my jab!

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Not sure if smallpox vaccines are easily available. But the mpox vaccine should also protect against smallpox.

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Mpox is exactly the route I will take. It’s free here (NZ). I just have to get creative about my sex life. My wife thinks it’s funny, but also has said I have to go outside our suburb to tell my stories and get my shot…. :smiley:

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Isn’t the mpox vaccine the same as the smallpox one?

e.g Jynneos

I agree. Absolutely appalling and unethical to carry out those experiments when the link between HepB and lifetime liver cirrhosis and cancer risk is extremely well known AND there’s an effective vaccine. Some countries, particularly in east Asia, had massive rates of chronic HepB and they’re almost down to zero now, and what a massive surprise - liver damage and cancer went way down too. Testing all-cause mortality is just ridiculous, and they’re hoping that the signal is lost in the noise and they can claim the vaccine does nothing.

I mean really, we’re almost back at a stage now where people are denying basic germ theory. The link between viruses and disease is well known, and the links between viral diseases a whole host of other human conditions is becoming better and better known.

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Yes - the trick is to ask for mpox (knowing you’ll also get smallpox coverage). If you ask for smallpox to address a very small tail risk, you’ll be declined. If you ask for mpox and tell them you have a colourful sex life, you get your jab…

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The science deniers are killing people and it will accelerate. I fear for my grandkids.

I never would have believed this could happen in my lifetime. It’s like we are going backwards to the dark ages of bleeding people and blowing smoke up their asses to cure cancer.

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On the upside, the progress in broadly neutralizing antibody vaccines may decisively defeat viral infections for anyone who gets them. The rest can use ivermectin and die.

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Here’s a nice article on progress in the field: The golden age of vaccine development - Works in Progress Magazine

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I believe coffee enemas are the done thing nowadays :slight_smile:

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