Use of Carnosine as a Natural Anti-senescence Drug for Human Beings

#44

That’s interesting, thank you. 10-12g of glycine is not an issue — i believe i saw a reference to a study on healthline or something like that which mentioned human studies have conformed that taking 90g of glycine daily in humans for a month wasn’t toxic. I’m already taking 6g of glycine and 30g collagen daily — the glycine as part of GlyNaC (with 200mg of NACET which could be between 1-4g of NAC equivalent, if you believe the “bioavailability” argument). I’m eating a heavily animal protein diet so probably high in methionine, so I’m working on the theory that more glycine could counteract the longevity detriments of methionine which could be the majority of the detrimental longevity difference between animal protein and plant protein consumption. And if not, then glycine is difficult to overdose on….

A few questions though:

o. Does “diabetic” in mice/rats mean type 1 (as in “no insulin production”)? Or does it mean high average blood glucose levels?

o. Is “L-glycine” the same as glycine we are all buying in kg bags? Or is it a derivative?

o. Is the mechanism for cataract prevention similar to preventing presbyopia? Meaning it (i think) should impact glycation in the eye lens specifically, which may have something to do with improving lens cell mitochondrial function?

Thank you.

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#45

o. Does “diabetic” in mice/rats mean type 1 (as in “no insulin production”)? Or does it mean high average blood glucose levels?

Reading the article would furnish the answer. The diabetes was induced.

Thirty-five of the rats were injected intraperitoneally with a single dose of streptozotocin (STZ; 65 mg/kg of bodyweight)

Three days after STZ administration, only the rats that have a blood glucose level of >15 mmol/l were considered as diabetic and were included in our experiments.

o. Is “L-glycine” the same as glycine we are all buying in kg bags? Or is it a derivative?

You could have done a search to make this a more collaborative exchange.

Summary – Glycine vs L Glycine

The key difference between glycine and L glycine is that glycine is an amino acid that makes up proteins, whereas L glycine is an isomer of glycine. When we talk about glycine, we actually talk about L glycine because it is the most stable and common form in biological systems. It is because our cells use only the L isomer. Further, this compound has many applications, including medicinal applications.

o. Is the mechanism for cataract prevention similar to preventing presbyopia? Meaning it (i think) should impact glycation in the eye lens specifically, which may have something to do with improving lens cell mitochondrial function?

The article’s conclusion provides the answer.

In conclusion, the present study shows that the administration of Gly to diabetic rats delays the onset and the progression of cataract by decreasing protein glycation, preserving protein content, potentiating the antioxidant system, and decreasing the activity of the polyol pathway in the lenses. Decreasing the serum Glc, AGE formation and HbA1c, in addition to the increase in the FRAP [Gly also increased the ferric reducing antioxidant power (FRAP) in the serum of diabetic rats.] are also other reasons for the beneficial effect of Gly on diabetic cataract. Gly did not show any toxic effect on the above-named parameters in the normal rats.

It is a short read. It would do justice to the scientists to read or skim their work in the original, instead of my summaries.

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#46

Thank you for your answers. I was in a spot i couldn’t pull up the paper and dig through it. I had hoped someone would have an answer off the top of their head and it wouldn’t be taxing. But in the future, if it is an inconvenience for you to answer the questions, i would not be offended or think less of you if you didn’t feel obliged to answer.

#47

Which type/types of collagen? Brand?

NACET, which brand?

#48

I thing 10-12 g of Glycine is easy to take. I aim for that daily already. Half in the morning with my coffee. The other half before dinner with my Citrulline.

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#49

Zen Principle hydrolyzed collagen peptides. In the convenient 55g drum. (Not really: 3 pound bucket).

Lipmaxmall NAC ethyl ester. 100mg capsules.

Both pasted images below:

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#50

I would be really careful about buying random eye drops from Amazon. There have been nasty incidents of infection coming from tainted drops that resulted in blindness and death.

Here the warning from the CDC:

Here is recent warning from the FDA:

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#51

Thank you. No intent in buying any. Have no need for any eye products.

I posted the link because people here were looking for a carnosine type eye product, without having to order from Russia.

Curiously, the CDC’s list of infected products mostly comes from big companies, not just amazon small sellers, as seen in your second link.

They include the following:

  • CVS Health
  • Leader (Cardinal Health)
  • Rugby (Cardinal Health)
  • Rite Aid
  • Target Up & Up
  • Velocity Pharma
#52

If I’m trying to reduce the negative effects of methionine from my heavily animal protein diet, I’m thinking that I probably should take more. I haven’t sat down and calculated out what amount is appropriate, but i assume more than 12g would be fine — maybe as much as 20g longterm. As i mentioned, one reference i saw mentioned 90g for a month had no measurable ill effects.

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#53

I saw that it. It makes me even more cautious about a product that might be made by a smaller company without the testing and safety protocols.

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#54

I’m also taking this although I can’t vouch for the company. Looks to be based in the UK and the website looks OK, but no 3rd party testing and little info on the web. From Reddit - “I couldn’t find it locally so I ordered “lipmaxmall” green/bluish bottle on Amazon.All positive so far, although I can’t find lab results or anything about the company, definitely not “long term” first choice seems shady but it’s cheap and I didn’t expect it to work so well.For NAC I used “NOW” brand, I tried another brand briefly and it was awful and had no effect.”
From scam-detector.com - “What does “Active. Mediocre. Medium-Risk.” mean? It is a business that’s been online for a while. It seems like www.lipmaxmall.co.uk has received both positive and negative feedback (occasionally), just like many other websites. That means that you need to exercise caution if you decide to proceed with using it.” I’m usually a stickler for quality, I think I only bought it because it’s NACET, a rarer form (and liposomal). You should investigate the quality of anything on Amazon.
Sharp eyesight, like a sharp mind, is something that matters to everybody, every minute of everyday. So whether it’s using carnosine eye drops or extra glycine or VUITY or Red Light Therapy or the peptide mentioned in the peptide thread, I think it’s important.
Between collagen (10 grams) and glycine capsules, I’m taking about 5 grams of glycine a day and maybe 2gr of NAC. It looks like I should up my doses. I may need the “big gulp” size of collagen, too (not 55 gal :grinning:). But in terms of collagen quality (I know it should go in the collagen thread)…I was taking Ancient Nutrition because it had type 2 collagen for your joints.
https://www.amazon.com/dp/B01LXADO9Z
But it’s expensive so I switched to basic collagen from Costco (type 1&3). Then I saw this:
https://www.amazon.com/NOW-Supplements-Hydrolyzed-Clinically-Validated/dp/B07HYXJ8Z7
And wondered, is Biocell Collagen better? There was also talk in the collagen thread that marine collagen was more bioavailable (one of my pet issues).

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Glycine+NAC vs Rapamycin
#55

The NACET smells like sulfur so at least there’s that, but this could be faked with any strong thiol.

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#56

Carnosine is one of the more expensive supplements out there.

Has anyone ever used the brand Axenic for anything? Are they trustworthy? They sell on eBay and Amazon and appear to sell some very interesting substance including things like SLU-PP-332, 5amino 1MQ.

If you know of any other affordable sources of carnosine I’m interested to hear.

I couldn’t find anyone talking about Axenic brand here, in Reddit or in any other website.

I might have seen it referenced in a study on Ellagic acid here: “The eligible patients according to the inclusion criteria were randomly divided into two groups: either 180 mg Ellagic acid (Axenic company) (n = 25)” The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple sclerosis patients with mild to moderate depressive symptoms: A randomized, triple-blind, placebo-controlled trial - PubMed

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#57

When I took carnosine, I used Nutricost. I didn’t really notice much so I discontinued it’s use as it is expensive.

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#58

I ended up going with Bulk Supplements. I might use a very tiny dose daily just for AGE prevention.

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#59

Bulk Supplements are very good with amino acids.

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#60

Am looking to buy N-Acetyl-Carnosine Eye Drops
Any suggestions?
@LaraPo

#61

I would try eBay. There are some listings there.

#62

Jonas, here is a link to one study on Can-C Eye Drops: N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: Glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population - PMC

  • The study was planned, organized, and supported by Innovative Vision Products, Inc. (IVP), a company based in Delaware, USA, that holds the worldwide patent for the NAC eye drop formulation used in the study. IVP is described as a pharmaceutical/nanotechnology company focused on ophthalmic products.

The study was favorable, but had small numbers of participants. So, I don’t have great confidence in it. In fact, I think it’s a worthless product, but that is just one person’s opinion. From my experience of using these eye drops for 6 months several years ago, I noticed nothing except a thinner wallet. But, they may work for you.

I bought from Amazon years ago, but no longer see the product listed there. Here are two websites that I know nothing about that list Can-C Eye Drops if you want to pursue this:

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#63

Thanks and @LaraPo