As it is known, nmn supplementation can reduce methyl levels in the body, since nmn’s excretion route is in the form of methylation. Methylation is critical for DNA repair and also for detoxification in the liver. Does anyone use betaine HCL as a methyl donor? What are the alternatives?
Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life - PMC.
I take 1g/day of betaine anhydrous from NOW. Difference from hcl:
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I use 2g of TMG and 500mg of pure choline as part of my stack.
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Are you worried about TMAO?
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It is concerning but I also have a fatty liver and choline supplementation has shown promise in reversing that condition in animals.
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Wrt. fatty liver, are you on any SGLT2i, GLP-1 agonists or any other pharma drugs? Seems like a first step (apart from lifestyle interventions).
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Doesn’t betaine hcl also give a methyl group like betaine anhydrous?
I am on empagliflozin and considering WeGovy.
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The empa should definitely help. 10mg or 25mg?
12.5mg taken in the morning.
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I take TMG every day as a methyl donor. That is betaine anhydrous.
I have not noticed anything from it, but I don’t take NMN or NR. I do have some B3 twice a week. I stopped taking NMN more than a year ago I can find out when, but I don’t think it matters.
I have been thinking more recently about mitochondrial DNA repair. Although I don’t think the symptoms of age related disease relate to a faiure of nuclear DNA repair I do think they relate to a failure of mitochondrial DNA repair and often it is the same enzymes.
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Rapamycin + Metformin has been shown to prevent fatty liver when combined. However, I’m not sure if they reverse it.
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Looks like Retatrutide may be the king of clearing out a fatty liver…
Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial
The addition of glucagon (GCG) agonist activity to GLP-1 agonism has shown promise for providing greater reduction of hepatic fat, an early marker of improvement in MASH.
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