So, is there an easy way for us to test to identify the ratio / balance of our innate vs. adaptive immune cells? We know that rapamycin helps prevent blood stem cell aging, so I suspect it has an effect on the stem cells mentioned below and it would be interesting if we could measure the effect in our bodies: Rapamycin Prevents Blood Stem Cell Aging, New MIT Study
What helps certain immune systems stay youthful and effective in combating age-related diseases? In a recent study published in Cellular & Molecular Immunology, USC Stem Cell scientist Rong Lu and her collaborators point the finger at a small subset of blood stem cells, which make an outsized contribution to maintaining either a youthful balance or an age-related imbalance of the two main types of immune cells: innate and adaptive.
Innate immune cells serve as the body’s first line of defense, mobilizing a quick and general attack against invading germs. For germs that evade the body’s innate immune defenses, the second line of attack consists of adaptive immune cells, such as B cells and T cells that rely on their memory of past infections to craft a specific and targeted response. A healthy balance between innate and adaptive immune cells is the hallmark of a youthful immune system—and a key to longevity.
Full story:
https://scitechdaily.com/usc-scientists-uncover-secret-to-a-youthful-immune-system/
Source Paper (open access):
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
by Anna Nogalska, Jiya Eerdeng, Samir Akre, Mary Vergel-Rodriguez, Yeachan Lee, Charles Bramlett, Adnan Y. Chowdhury, Bowen Wang, Colin G. Cess, Stacey D. Finley and Rong Lu, 24 October 2024, Cellular & Molecular Immunology .
DOI: 10.1038/s41423-024-01225-y