sadly, I received the package from MitoPure (a package with a card that you dripped some blood onto) but I got busy and never sent it back to them. So, never got any results. It is still of interest to me. Apparently its a pretty simple test. Not sure if anyone else provides it.
Well as far as I can tell, the study that determined the 40% number only came up with that by dosing subjects with pomegranate juice. Prior to that, they could only detect a small amount in 12%. So my inference from this is that this supplement would likely be useful to all regardless.
https://www.nature.com/articles/s41430-021-00950-1
Only 12% of subjects had detectable levels of UA at baseline. Following PJ intake ~40% of the subjects converted significantly the precursor compounds into UA. UA producers were distinguished by a significantly higher gut microbiome diversity and ratio of Firmicutes to Bacteroides. Direct supplementation with UA significantly increased plasma levels and provided a >6-fold exposure to UA vs. PJ (p < 0.0001).
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Yes. I’m a regular consumer of pomegranates at this time of year (never the juice) so I was interested in this. But otherwise, yes, most people would need to supplement.
The issue of course, is the cost/benefit ratio of supplementation, which is very hard to determine.
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Just recovering from a lingering virus and feeling a bit energyless in convalescence. So i thought id invent a 30 day pomegranate protocol to kitchen sink some mitophagy:
Kefir + chia + flaxseed + pomegranate arils + molasses + pom peel powder + what germ (for spermidine)
Im also throwing in some ubiquinol just in case.
VO2 max had dropped to 44 and Im interest to see where it gets to in 30 days.
Not very scientific/controlled but an interesting case study in what can be done for post viral burgh
Any other ingredients suggestions?
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Indeed. The Safety Data Sheet for Urolithin B is alarming. Now this may be a case of CYA by corporate lawyers, or it may refer to a laboratory grade of the substance, but the SDS says U-B is highly toxic, causing eye, skin, and respiratory irritation.