FWIW, I was using gethealthspan’s UA, but recently switched to Aeternum for their better price
I read some comments on this forum saying they thought it was a legit brand, however it was only a handful of comments. (If anyone thinks differently, please chime in!)
I bought it during one of their many sales. Note, each serving is 1000mg, and each pill is 500mg, so it’s a better value that it appears at first glance.
also, no fillers.
And, I see no evidence that Timeline contains CoQ10? I am curious because I need to take that and getting two things in one would be appealing.
Again: even assuming UA is all that, there are no studies that I am aware of which show what interaction, if any, there is between UA and rapa and/or SGLT2i or other drugs/supplements. Are you willing to take UA without any information regarding such potential interactions? I am not, because I have researched rapa and some of its interactions with some drugs (such as SGLT2i) that I also take, and since I like what I read about these, I don’t want to risk throwing UA into the mix potentially interfereing with them. I will wait for more information before even thinking of getting on UA. YMMV.
Excellent points, as always. And I always appreciate how exacting you are.
Because, as always, I have zero clue, I did run by the idea of taking it by a smart longevity doc, the one we all know and love, and he felt it was probably a worthwhile thing for me to add, and knows I’m on dapagliflozin and rapa.
I’m definitely not married to it and assumed it was a no harm and might possibly be beneficial proposition.
I’d want to be more convinced of benefits before spending $$$ on Time Line. Having said that, if it also contained the coq10 I need (I’m was shown to be deficient), I’d consider paying for the convenience of taking one thing vs two, especially because they have some new gummies that are supposedly yummy :).
Q10 might have other benefits. However, the paper you cited says: “Patients with heart failure were given coenzyme Q10 at doses ranging from 30 mg to 400 mg per day in the studies included. There was no determination of the minimum and optimal doses for coenzyme Q10 use, and further dose-response analyses will be required in the future.” And we know that Q10 has a weird dose-response: Coenzyme Q10 (CoQ10) U-shaped dose-response relation with blood glucose and blood pressure
The eminent researcher of mitochondria, Dr. Mark Tarnopolsky, MD, PhD, gave an interesting interview about mitochondria in general and ways to boost them and preserve their health. In passing, he expressed extreme scepticism toward the utility of Urolithin A, and debunks some of the prominent studies of Urolithin A (approx. minute 25). He’s also pretty unenthusiastic about NAD.
Dr Mark Tarnopolsky, MD, PhD | Mitochondrial Mastery: Supplements, Exercise & Longevity Insights (degrees of health)
Our multi-omic analyses reveal that UA reorganizes ER, mitochondrial and lysosomal networks, linking inter-organellar dynamics to mitochondrial quality control.
In C. elegans, UA induces calcium release from the ER, enhances lysosomal activity, and drives DRP-1/DNM1L/DRP1-mediated mitochondrial fission, culminating in efficient mitophagy.
Similarly, in mammalian cells, UA increases intracellular calcium, enhances mitophagy and mitochondrial metabolism, and mitigates stress-induced senescence in a calcium-dependent manner.
For anyone interested in Timeline Urolithin A, it is on sale now, 40% off. I just bought 3 on Amazon…
Neurogan price for their Urolithin A product looks tempting but they were unable to provide me a 3rd party COA showing how much Urolthin A was actually in the product. I doubt there is any.
I was never willing to spend on those, but I’ve been curious about the gummies, so I pulled the trigger and chose the subscription for 46% off!
FYI, I checked and saw they are offering 40% off on their website, but they link Amazon as an option, and that way I could lower the price a touch by choosing subscribe and save. If they didn’t offer that link, I would not have known I could trust the amazon source.
Still most likely overpaying for no reason, but if I can have a yummy gummy, it was worth a gamble. FWIW, I’ve been taking Aeternum brand.
ConsumerLab reports that tests done by SuppCo showed that Neurogan, CodeAge, Pure Encapsulations and Timeline contained the claimed amount.
Neurogan being the cheapest.
I have been taking 1,000 mg/day of Urolithin-A for over two months, which is one of three periods of time required to produce different types of benefits. Two months is the target period for beginning to see measurable functional gains in muscle endurance. As someone over 70 who has experienced increasing challenges in fatigue and recovery time related to exercise over the past few years, I can report a significant improvement in both. A few years back, I did strenuous 45–60-minute mountain hikes 4-6 days a week. Gradually, these hikes became more challenging in terms of muscle soreness and especially recovery time. This past year, I have had to allow at least four and sometimes six days to elapse before I could hike again. The most interesting change I attribute to Urolithin-A is how the improvement, especially in recovery time, manifested itself. The change was almost binary. For most of the two months, I felt no effect at all. I had committed to giving the experiment a four-month run but was beginning to think I was wasting my time and money. Then, recently, I want for a hike that immediately felt like it did several years ago. The soreness was typical for the level of effort at any age but the recovery period was ~24 hours and the soreness was gone. I was eager for another hike! I do not have exact records but I estimate that it has been 15 years, maybe 20, since I felt that way. According to the research I have reviewed, this effect begins to manifest itself at around two months and plateaus at four months. I will report again at that time. I’m not going to take the time to detail the reasons I attribute these gains to Urolithin-A and not to other environmental, biochemical, or psychological effects but I am careful to rule such possibilities out to the extent possible in these contexts.
For most of that time, I have used aeternum. I’m switching to Neorogan because they had a discount offer on Amazon and they seem to be one of the most used brands.
Given that the improvements seem to be to a younger period and nothing beyond that, I wonder if younger people would experience meaningful benefits from Urolithin-A.
I’m wondering the same. I think at the very least, it wont do any harm and at best, prevent any age related decline in whatever the Urolithin A is supposed to improve. The same can probably be said about a lot of interventions like GlyNAC for instance (which works in different ways).
