This is why I love this site!
I am grateful you shared your story because I was going to try my first larger dose tomorrow, with the idea of going to every 14 day dosing.
I am traveling tomorrow and it completely slipped my mind that I might have all sorts of exposure. I’ll now wait until I return.
Thx again, and sorry you got so sick.
What animal models are they referring to which exhibit the “transient” inhibition resulted in “successfully reversed aging phenotypes”? Insofar as I’m aware, the vast majority of rapamycin studies in animals were continuous exposure. The prominent studies where weekly dosing was used were the cat HCM studies where aging was not an endpoint, and MK’s dog project (where we don’t have the full results as yet).
There have been about half a dozen mouse studies with periodic, or interval dosing of rapamycin. Here is one…
I think it is. My background CRP has crept up a bit. I think I know how I can get it back below 0.15mg/L. My last few weeks results were: 0.26 0.29 0.4 0.35 0.57 0.32 1.51
I take Monday’s result (remembering I test this every week) as meaning I was infected in some way. I am not clear on what this is, however. I am due a Rapamycin dose on 1st May, but I am going to delay this until after my wife’s election result which is 8th May because I don’t want to have a low immune system whilst supporting her in an election campaign.
I take rapamycin to encourage selective mitophagy. I think this feeds into background CRP via a reduction in senescence, but senescence is in part caused by a reduction in SLC25A1 through IL-10 and the Janus Kinase. (this is a mechanistic hypothesis with some evidence).
One of the things I have not been able to get useful information on is whether it is possible to encourage selective mitophagy in the stem cell stores which are held in a hypoxic environment and to some extent a state of dormancy.
What I would suggest to people going for infrequent larger doses (which is what I do) is to build up gradually to minimise the chance of negative side effects.
I was hoping for some guidance, other than from Claude!, so thank you!!!
Recently, I’ve been dosing 5 mg rapamycin every Monday. With my workweek schedule, workouts stay lighter than the intense sessions I save for weekends.
As a carnivore dieter, I’ve sustainably dropped 40 pounds, right to my limit without calorie counting or suffering…and it’s held steady for two years. I can eat as much fatty meat as I want. At 6’6" (factoring in some age-related spinal compression), I’m 245 lbs. now; 225 was my skinny high school weight. Feeling solid at 64 years young, and with 5 mg, I’ve avoided cold sores (which I hate) or other adverse effects.
In my view, we don’t really know the optimal dose yet…Dr. Matt suggested in his Dr. Brad YouTube interview that 6 mg might be too high for older folks. So my confirmation bias says 5 mg could be better. I also wonder about dose timing around exercise: Maybe we should hit hard workouts every day except recovery, and if muscle gains are blunted post-rapa, so what?
From the mice studies and Dr. Blagosklonny’s papers, I strongly disagree. In fact I am betting my life on it
Not disparaging Dr. Stansfield, but comparing credentials with Dr Blagosklonny’s and Dr. Blagosklonny’s lifetime practice. I choose to follow Dr. Blagosklonny’s advice. Each must choose their own path to follow.
“Later, experiments in mice suggested that low doses are suboptimal”
“In mice, the higher the dose, the longer lifespan.”
"Therefore, in humans, the highest dose that does not yet cause unacceptable side In mice, the higher the dose, the longer lifespaneffects (maximal tolerated dose) may be optimal for longevity. If (unacceptable) side effects develop, the dose should be decreased.
“Side effects of rapamycin are not remarkable at all. They are even less dangerous than the side effects of most other drugs.”
You might be right! We will see. The expert who made the comment was Dr. Matt K., and I think the comment was more directed to hypertrophy versus longevity.
IMO it is a question of trough levels rather than dosing.
Dr. Alan Green took 10mg per week and he saved himself many years in life after knocking on deaths door with heart problems. Hes another good anecdote
Like @desertshores he was old as methuselah… and had significant heart issues… as with Blagosklonny and his decades of cancer, so maybe beneficial when in one 's 80’s 
. When I went up higher 10 -12 mg in my early 60’s…I got a negative effect… turned my MTOR1 too low. Started aging biological markers faster after a year of solid reversals. Good to monitor with tests…I use GlycanAge for inflammation and TruMe Labs for DNA Methylation.
Let’s see if I get old enough to try higher…glad I started at 6 mg at 60’s.
If I was 40… wouldn’t do more than 4 mg… 2 mg at 30. Could be a pattern 2 mg for every decade starting at 30. As I near 70… I have been popping up to 8 mg every few doses or so.
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As i have said previously, the trough matters. mTOR has a role to play and should be uninhibited from time to time.
I wouldn’t dare go near him as an example of having benefited from RAPA. I don’t usually like anecdotes that are based on oh if he didn’t take Rapa he would have died way earlier. How would you/I know that? How about playing devil’s advocate and saying if he didn’t take Rappa he would have easily lived another 10 or so years by watching his lipids and doing SGLT2, Eze, and Pita and maybe metformin as an example. While his ills to start may have had nothing to do with Rapa, perhaps RAPA signed off his demise by wrecking his immune system? Who knows - right. Bottom line the guy dropped dead before he was even 80? I think (and was taking RAPA). That is NOT a very good sign if you were to ask me. Find me an example of a guy/gal that was taking Rapa regularly and they are (or lived) at least to a 100, then I’ll accept it. As a rule of thumb, I’d say that every time someone whose taking Rappa dies before reaching 90 (regardless of the cause) we should call that a very bad sign and every time someone that’s taking Rappa dies and is over 100 we should consider that a very good sign. If’s and but’s and other scenarios can fly around and every conceivable direction LOL. The best we have so far is @desertshores which his case is very promising, I’ll admit to that, but regardless of how much I search and search all over I have yet to come with a concrete case of a human being past 90 that has been taking rapa say in last 10 years, or even 5. Until that becomes the norm (meaning there is a lot of people that fit the category, I’m going to be VERY skeptical while still continuing to take RAPA.
Having said that I do take RAPA myself but I’m not the one to make up stories in my own mind to convince myself that RAPA will help me live longer. I’m gonna be brutally honest, while I think RAPA has probably helped some with inflammation and joint discomfort, I can also attest that couple times I have had very nasty cold like symptoms (way worse than what I would normally have when used to get sick pre RAPA days) which actually were so bad that I was thinking to myself, imagine if I’m in advance age (77+) and getting this kind of symptoms most likely won’t be able to make it. I’m almost certain that RAPA was the culprit of the worsened symptoms via destruction of the immune system, while the cold itself might or might not have been affected by it. So, keep that at the back of your mind that in case you might get hit with some nasty virus or cold etc. RAPA may not be your best friend. I’m even tempted to think that RAPA will be a contributor to one’s demise should a nasty viral infection were to occur when you are in advance age. I do however believe that for those lucky ones that have never had any bad side effects from RAPA then the benefits should far out way the risks. For unlucky ones (unfortunately I tend to be in this group) that we tend to often get side effects the opposite may be true.
Again, I’m not giving up on RAPA yet, but I’ll be very open minded and watching it closely as I go along.
I don’t know why and this is entirely based on anecdotal and how I feel but I am starting to think that a combination of PITA, EZE, EMPA, TELMISARTAN, and perhaps Metformin may offer WAYYYYYYYYYYYYYYYYYYY more benefits for longevity than Rapa(which to me means reaching about 105 years old, because beyond that there is nothing that we know of as of now that can subjectively help). I take them all and can attest to NOT being able to identify any side effects at all while absolutely getting HUGE benefits in way of lower glucose, lower inflammation, and lower lipids. Just my unbiased and untainted (by euphoria and placebo LOL) opinion. BTW, this is my earnest opinion, and it is absolutely not meant to be argumentative in any way shape or form.
If I may ask, was your renal failure due to antiphospholipid syndrome (APS) by any chance? There are several case reports of stellar improvement in the microangiopathy of APS patients when rapamycin is added to the drug regimen of these trasplant patients. The Reader’s Digest version is APS antibodies attack the intimal lining of renal microvasculature => mTOR overactivety => thickening of the intima => sluggishness of blood flow in these tiny vessels => clots forming => tissue death. Rapamycin knocks that overactivity down, the intimal thickness regresses, and blood flow is restored.
Keep in mind that regarding heart health specifically, rapamycin is heart protective. We know this from validated studies in pets. To the point that a rapamycin formulation is actually FDA approved for a heart condition in cats (HCM) - that’s about as rigorous as it gets. Matt Kaeberlein’s idea of testing rapamycin in dogs was that dogs age similarly to people, suffer from a similar range of diseases and share our exact environment, and so are an excellent model for human aging. From preliminary results (the sudy is ongoing), there are reports that rapamycin actually reverses aging of the heart, and brings it back to more youthful functionality. Therefore it seems eminently sensible that Dr. Green would select rapamycin to treat his heart condition, which he claimed helped him greatly. We all are gambling, but regarding heart health, I personally am pretty sanguine about the impact of rapamycin on my heart health. YMMV.
Agreed it’s a gamble, but I view it a as semi-informed gamble that can be mitigated with pauses etc.
A story on Dr. Green piqued my interest in rapamycin many years ago, and started dosing 5+ years ago.
That said, I’ve taken breaks and now am coming off my longest break of about 6 months and looking for advice on reintroducing. I took up running and paused to not mess with Boston training. With the race last Monday, I’m looking to both start dosing and continue training (I’m hooked 
). I’ve liked my prior 6mg/10 day routine which I’d take on easy or off training days.
Would love feedback from the geniuses on this board.
Thanks
No, it was because of food poisoning.
I hear you, but apparently, it either didn’t help him much (but he thought it did), or it wasn’t enough help. Either way he’s dead and he was taking RAPA. Not good in my books regardless of what anyone thinks. I definitely need to see cases of people being in their late 90’s and hopefully 100’s that seem relatively healthy and have been take RAPA for a while to be convinced. Until such time count me as being very sceptical, while I am still taking it though, which is to say I’m not against it yet. But instead of being say 100% pro, I’m more like 60-65 pro and 35-40 against. Everything else I take I’m 100% pro, not even a 1% doubt that I’m benefiting (greatly) by taking them.
Again, I think Rapa is a perfect case of reward vs risk. For some people there seems to be no risks (or very low) for others there are risks of lipid and glucose moving in wrong direction plus infections and other sides. I always love it when I take something and don’t feel any negative side effects while reaping the benefits. and, for people with no side effects from RAPA I do think they are benefiting from it overall. But if you happened to have to take other meds to counter the side effects of RAPA as an example (or any other med for that matter) then to me it beats the purpose. Why not stick with the substances/meds that you know are not negatively affecting you, yet they are benefiting you greatly with better markers, while still showing pretty convincingly longevity benefits, i.e. SGLT2i’s, Acarbose and many others.
Again, I don’t call it a gamble at all if I take something and have ZERO side effects while the benefits show right away in the labs. As I said earlier been taking Empa, EZE, Telmi, Pita, ACA, and meftormin all of which have shown to increase lifespan (some more, some less) and I have absolutely no negative side effects. I love them! As far as RAPA, well can’t say I love it. One thing is for sure that If I get one more cold/flu case with symptoms near or as bad as last one I had couple weeks ago (it started two days after taking my Rapa dose) you can rest assured that all my 1000 pills of RAPA will be thrown in the garbage, but being that I’m a bit of vengeful type of guy, I might actually burn them first, and to NEVER look back at it again LOL. No, thank you I’m not going to continue taking something that continues to make me sick, and If I were to continue then I’d agree with you, that is pure gambling. As far as the other 5 or six I listed earlier and I love don’t see much gambling there. Even my anion GAP (whatever that is) that has persistently been higher for last five years dropped to “optimal” out of nowhere and i didn’t even expect it at all on my last test. Out of convenience, (and maybe a good guess) I dedicate that improvement to SGLT2i/EMPA even though I had started couple other substances at same time and after my last test (i.e. Telmi and Sele) but it definitely wasn’t Rapa because it kept showing as too high even long after I had started Rapa.
Just my unvarnished opinion but in all honesty if I were to have no side effects from it, or if my sides somehow disappear going forward, I will definitely continue using it.