Interesting, I just had a nasty infection with Norovirus that started on Monday, April 13th. It started on afternoon after my morning dose of rapamycin 6 mg. I was exposed to a person with symptomatic on Saturday, April 11th, so the incubation was a perfect 48 hours. I didn’t realize they had Norovirus, they told they were have some GI issues. Have I known I was exposed to the virus I probably would have skipped the dose.
I remembered contracting Norovirus last year from my wife and it wasn’t nearly half as bad - and she didn’t even isolate. My wife didn’t contract it from me but I did sleep in a different bed.
So, yes I skipped the dose last Monday and rethinking the dosing schedule of the rapamycin. Another reason my labs from yesterday showed a reduced WBCs and hs CRP under 1. This is a very low state of inflammation which I also attribute to my super strict diet and exercise regimen. Low WBC may also be post-infectious. I wonder if someone has a very low state of inflammation… is rapamycin even still helpful ???
What animal models are they referring to which exhibit the “transient” inhibition resulted in “successfully reversed aging phenotypes”? Insofar as I’m aware, the vast majority of rapamycin studies in animals were continuous exposure. The prominent studies where weekly dosing was used were the cat HCM studies where aging was not an endpoint, and MK’s dog project (where we don’t have the full results as yet).
I think it is. My background CRP has crept up a bit. I think I know how I can get it back below 0.15mg/L. My last few weeks results were: 0.26 0.29 0.4 0.35 0.57 0.32 1.51
I take Monday’s result (remembering I test this every week) as meaning I was infected in some way. I am not clear on what this is, however. I am due a Rapamycin dose on 1st May, but I am going to delay this until after my wife’s election result which is 8th May because I don’t want to have a low immune system whilst supporting her in an election campaign.
I take rapamycin to encourage selective mitophagy. I think this feeds into background CRP via a reduction in senescence, but senescence is in part caused by a reduction in SLC25A1 through IL-10 and the Janus Kinase. (this is a mechanistic hypothesis with some evidence).
One of the things I have not been able to get useful information on is whether it is possible to encourage selective mitophagy in the stem cell stores which are held in a hypoxic environment and to some extent a state of dormancy.
What I would suggest to people going for infrequent larger doses (which is what I do) is to build up gradually to minimise the chance of negative side effects.
Recently, I’ve been dosing 5 mg rapamycin every Monday. With my workweek schedule, workouts stay lighter than the intense sessions I save for weekends.
As a carnivore dieter, I’ve sustainably dropped 40 pounds, right to my limit without calorie counting or suffering…and it’s held steady for two years. I can eat as much fatty meat as I want. At 6’6" (factoring in some age-related spinal compression), I’m 245 lbs. now; 225 was my skinny high school weight. Feeling solid at 64 years young, and with 5 mg, I’ve avoided cold sores (which I hate) or other adverse effects.
In my view, we don’t really know the optimal dose yet…Dr. Matt suggested in his Dr. Brad YouTube interview that 6 mg might be too high for older folks. So my confirmation bias says 5 mg could be better. I also wonder about dose timing around exercise: Maybe we should hit hard workouts every day except recovery, and if muscle gains are blunted post-rapa, so what?
From the mice studies and Dr. Blagosklonny’s papers, I strongly disagree. In fact I am betting my life on it
Not disparaging Dr. Stansfield, but comparing credentials with Dr Blagosklonny’s and Dr. Blagosklonny’s lifetime practice. I choose to follow Dr. Blagosklonny’s advice. Each must choose their own path to follow.
“Later, experiments in mice suggested that low doses are suboptimal”
“In mice, the higher the dose, the longer lifespan.”
"Therefore, in humans, the highest dose that does not yet cause unacceptable side In mice, the higher the dose, the longer lifespaneffects (maximal tolerated dose) may be optimal for longevity. If (unacceptable) side effects develop, the dose should be decreased.
“Side effects of rapamycin are not remarkable at all. They are even less dangerous than the side effects of most other drugs.”
You might be right! We will see. The expert who made the comment was Dr. Matt K., and I think the comment was more directed to hypertrophy versus longevity.