Ultra Low Dose Everolimus-Side Effect Profile vs Rapamycin

Good day folks. Quick recap: I stopped rapa months ago after developing slight swelling on my left cheek which was due to a very rare condition that has been linked to rapamycin (essentially the rapamycin caused a build up of a particular protein). It usually resolves when ceasing rapa. It has not for me but has decreased somewhat and only I really notice anything now, given we are generally our own worst critics.

I switched to acarbose (50mg two-three times a day dependning on frequency of my meals…on it for past 10 weeks or so) and apart from the widely reported flatulence, its been well tolerated.

I do wonder though, given I do not wish to give up on the mTor inhibitor route entirely, if the everolimus analog might be a better option given its shorter half life. Could this-in theory-lead to a better side effect profile if one does NOT increase the dosage to compensate?

Oh I should add the doctor who is monitoring me said, and I quote: “It’s worth a try” :laughing:

Can you say more about this effect?

Also, if you have a dr that is ready to prescribe you everolimus, wow what an adventurous dr. I’m impressed!

Ah yes of course. Knowledge is power: It caused-or rather it seems most likely culprit for an accumulation of abnormal amounts of mucin in a very contained area of my cheek.

Re my doctor, yes he seems fairly relaxed (as you might have gathered). He is a telemedicine doc who reviews my bloodworks and regimen remotely. He was willing to prescribe acarbose (and I guess the everolimus too) but it’s much cheaper to source from India and have him simply monitor.