TRT therapy alongside Rapamycin

Anyone know if TRT negates the shutdown of mTOR1 by Rapamycin. Am I flipping off the switch with RAPA only to turn it back on with the TRT?


I don’t know what exactly binds to mtor to activate it but rapamycin effectively blocks the binding of other molecules so it shouldn’t really matter. I don’t know how old you are but before you commit to TRT I would try to get my testosterone as high as possible without interventions that basically will put me on medication for the rest of my life, things that boost T: lose visceral fat ,get enough sleep, protein and good fats, resistance training, vitamin D, having sex with an actual partner, boron, zinc, ashwagandha, d-aspartic acid (somewhat in that order)


Thanks for the reply! Most helpful.

I don’t do ashwaganda regularly ( but I do use it), and I don’t take d-aspartic. Otherwise I check all those boxes, though I’ve not been on Boron very long. I’ve been on TRT for 6 months and the the results are pretty life changing, fwiw.



The Agess RX group… doing the PEAL Clinical trial… sponsored a presentation yesterday with Dr. Ross Pelton… he wrote the book on Rapamycin… literally.

He stated that Rapamycin, Testosterone and Metformin are compatible together and he recommends all three for slowing aging. I do Metforinn 500 mg 1 time per day… 10 mg Rapamycin on Monday once per week…and 1ml 200mg cypionate once a week on Thursday for past 2 years. I like separating Rapamycin and Cypionate by 4 days. Works.

All great. Chronological age 64.
Biological age 37based on GlycanAge.


So 53 yo here. Same dose Metformin and Testosterone, but 6mg Rapa. Did you try 6 before 10? Improvements or increased side effects 6 vs 10? (I do get the mouth sores, but tolerable).

Appreciate the feedback!


Hey there!

So I started TRT… 3.5 years ago.
Then 2 years ago. …added rapamycin at 6mg once a week… full amount… no side effects for 1.5 years. Upped to 10 mg for last four months… then for 2 monthsApril May 2022. I have been taking 10mg with a glass of grapefruit juice … when I take the grapefruit juice with it… 24 hours later, I get diarrhea for a day…

I might go 10 mg… no grapefruit juice next time…

Started taling one 500 mg pill of Metforinn daily … started a year ago.

Never had any side effects.
Just improvement.
Arthritis gone, swallowing issues gone, allergies gone, strength and good skin.
Gums and hearing improved. Memory so amazing. Remember everything lately from the past.

All good…