Blagosklonny’s new paper. Perhaps review this and forward questions to @Krister_Kauppi for his interview: Questions to ask Mikhail Blagosklonny?
Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a particular disease that is expected to be life-limiting in a particular person. Age-related diseases, quasi-programmed during development, progress at varying rates in different individuals. Rapamycin is a prophylactic anti-aging drug that decelerates early development of age-related diseases. I further discuss hyperfunction theory of quasi-programmed diseases, which challenges the need for the traditional concept of aging itself.
Currently, doses and schedules of rapamycin for longevity are based on the wrong objective: to avoid side effects. Nothing else. The doses of all other drugs are chosen to achieve therapeutic goals. For aspirin’s example, rheumatoid arthritis patients received high-dose aspirin (3600 mg/day) daily [31], while for prevention of cardiovascular diseases we use low-dose aspirin (81 mg). Depending on the pathology, aspirin usage can be intermittent or continuous [32, 33]. Side effects avoidance is a secondary goal, even though side effects may be deadly.
Side effects of rapamycin are not remarkable at all. They even less dangerous than the side effects of most other drugs [34, 35]. Since 1999, millions of patients with serious illnesses tolerated rapamycin well. Continuous (everyday) even high doses were studied successfully in patients [36]. A failed suicide attempt (103 tablets or 103 mg) caused no effects except elevated blood lipids [37]. In some studies, side effects were higher in the placebo group than in the rapamycin-treated group [38].
In that interview he mentioned this paper and I really like the part that the aging is replaced with the term age-related diseases. It makes the theory more elegant in a way and easier to take in 
