4 Likes
Thanks for posting. I love the slide that compares mTOR regulation of young vs. old when fasting! To replicate this regulation would require shorter half life rapalogs possibly taken at night during fasting phases.
2 Likes
This seems to show that intermittent dosing of rapamycin in mice improves lifespan.
Very good presentation. Hopefully the drug TOR101 will be affordable with a large supply if successful. Increase in cholesterol still a downside with these potential superior rapalogs. Hence it is not automatically the case that mTOR inhibitors will improve healthspan. It probably requires a cholesterol lowering drug on the side.
1 Like