Here is a list of the papers we like most. To really understand how rapamycin functions in mammals, and its potential benefits and risks it helps to actually read the full research papers that have been published, and that are (ideally) from double blind, placebo controlled studies. We have also included at the bottom of the list some papers on other drugs that have performed very well in lifespan extension trials in mammals - Canagliflozin, Acarbose and Alpha-17 Estradiol.
Here is a list of the rapamycin in mice papers we like:
Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in...
Three months treatment with the drug rapamycin increases lifespan, alters cancer prevalence, remodels the microbiome, and improves functional measures of health in middle aged mice in a dose- and sex-dependent manner.
Rapamycin in Dogs and Monkeys:
Age is the single greatest risk factor for most causes of morbidity and mortality in humans and their companion animals. As opposed to other model organisms used to study aging, dogs share the human environment, are subject to similar risk factors,...
This report is the first description of dosing procedures, pharmacokinetics, biochemical action, and general tolerability of the antiaging drug rapamycin in the common marmoset, a small and short-lived monkey. Eudragit-encapsulated rapamycin was...
Rapamycin Human Clinical Studies:
Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays the onset of age-related diseases and comorbidities. However, it is unknown if mTOR inhibition affects aging or its...
Canagliflozin (SGLT2 inhibitor) for Anti-aging:
Acarbose in Anti-Aging (mice);
To follow-up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at...
Alpha-17 Estradiol
Four agents--acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB)--were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22%...
