Taurine will produce sulfide smelling gas if it reaches the colon. Taurine has high affinity to the taurine transporter, so it’s unlikely that other amino acids will cause taurine malabsorption such that it makes it to the colon. The only notable exception is Beta-Alanine, which has a higher affinity for the taurine transporter. Given taking it away from Beta-Alanine, that practically leaves two options for why it’s making it the colon a) the transporters are saturated → take less taurine at once b) it’s moving too quickly through the digestive track to be absorbed → probably also just take less at once.
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Glycine also blocks Beta Alanine and Taurine because all 3 use the Glycine receptor. Best to take these three separately and on an empty stomach.
Interestingly caffeine also blocks taurine absorption but they also enhance each other.
The receptor can be activated by a range of simple amino acids including glycine, β-alanine and taurine, and can be selectively blocked by the high-affinity competitive antagonist strychnine.[2] Caffeine is a competitive antagonist of GlyR.[3] Cannabinoids enhance the function.[4]
Marijuana enhances the absorption of Taurine and Glycine.
But stay away from the strychnine. 
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Would you like to be able to easily see what other people are doing and have this information aggregated? I saw that request on this forum before and just built a beta site to help do that. If you’d like to help influence design and get this off the ground, looking for a few people to do a short user testing session 
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I’d love to test it!
Awesome! I’ve sent you a message.
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It would need to be editable as stacks often change.
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Yes, agree! Does allow for editing and creating multiple different stacks.
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I’m still relatively new to this forum and the plethora of interventions in use. I like seeing what others are doing … yet at times it is like reading Klingon. One thought on the this database:
It would be very helpful to have a reference “library” for what each intervention is and what it is intended to accomplish, to help me determine if it fits with my own intentions and needs. If this already exists somewhere, I’d love to get a link to it. Frequently, a simple list without the intent for each item is simply confusing … mostly for those of us who are just joining this journey.
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Great suggestion. I can add that.
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If you are serious about wanting a reference library for the supplements, its probably best to subscribe to a service like Examine.com
Unfortunately they don’t provide much of anything for free, its paid.
The alternative is, I suspect wikipedia, which is really not that helpful or takes much more time to understand: Spermidine - Wikipedia
There must be some open databases on this type of issue. I know that @Gokhan has a personal list on his blog that is quite good as a place to start:
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The list below was my personal compilation of what I deemed as “relevant ideas” mentioned above in this thread. My criteria was admittedly subjective and totally biased based on my years of personal research. My goal in the compiling this outline was to organize the inputs into a useful “shopping list” of credible ideas, including things I may have overlooked. I wanted to see what was mentioned that I may not have fully investigated yet, as well as what overlaps with my current practices. I share the outline below in case it’s helpful…
Life * Habits
- Exercise
- Cardio
- Strength training
- Healthy diet
- Avoid sugars
- Avoid processed foods
- Adequate protein
- Diverse fruits and vegetables of many colors (polyphenols)
- Gut Health
- Avoid antibiotics
- Avoid processed food
- Increase fiber
- Increase polyphenols
- Increase fermented foods
- Akkermansia
- Periodic energy shortages.
- Fasting
- Time restricted eating
- Sleep
- Sauna/Cold Plunge
- Social Karma (friends, hobbies, passion for life, meaningful work)
- Things To Avoid:
- Sunburn
- AGEs in diet (advanced glycation end products from food cooking)
- Drugs to wake up and/or drugs to fall asleep
- Alcohol
- Mouth breathing
- Smoking
- Pollution
- Tests/Screenings
- Regular bloodwork
- Cancer (generally, the Grail test)
- Cardiovascular (CAC and MRI)
- DEXA scan
- Proper body mass index
- Monitor and reduce visceral fat
- Blood pressure
-
Supplements (both prescription and over-the-counter)
- Rapamycin
- Senolytics
- Dasatnib+Quercetin
- Fisetin alone
- Quercetin alone
- Lipid Lowering & Reduce APOb (controversy on this topic)
- Rosuvastatin
- Ezetimide
- Atorvastatin
- Glucose Management (reduce insulin/IGF signaling)
- SGLT2i
- Empagliflozin
- Metformin
- Acarbose
- Curing Deficiencies
- Vitamin D3
- B 12
- Omega 3 Fish Oil
- Magnesium
- Vitamin K2 (MK4 & MK7)
- Amino Acids
- Taurine
- GlyNAC (some people choose Glycine only without NAC)
- Creatine
- Collagen
- PDE5 Inhibitors
- Low dose tadalafil
- Sildenafil
- DHEA
- CoQ10 Ubiquinol
- Hyaluronic Acid
- Lithium
- Astaxanthin
- Sulforaphane
- Photobiomodulation (Red Light Therapy)
- Worth noting – nobody with knowledge is using Resveratrol or NAD precursors.
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True. Examine was an initial thought for me too, at least for supplements. Good suggestion from @Steelart99 to highlight the intention of each intervention and then maybe provide further links. In the end, there isn’t a bulletproof solution as too many things either lack RCT’s and/or have many conflicting opinions on effectiveness. Guess that’s why we’re all here trying to figure it out!
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Both examine and consumerlab are worth every penny. Amazing resources.
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How do you do cancer screening and how often?
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Colonoscopy every 5-10 years.
PSA yearly
Mammograms every 2 years
Dermatologist skin survey yearly
PAP smears every 1-2 years
HPV Vaccine
There are probably others
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I was taking 250mg of bulk powder in an extended release capsule until recently. For about the last month since taking an early retirement I’ve been taking a break from most of my supplements/meds except rapa, my estradiol patch and two 10mg capsules of melatonin with glycine before bed just to get more of a baseline on how I feel without the excessive work stress. I’m going to get labs soon to see where I’m at with this minimal stack before adding anything back in.
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KarlT, Ah, yes, the HPV vaccine! My doctor is a stickler for following that Recommended Vaccine Chart without listening to my reasoning. I told her I can afford to pay out of pocket, but it didn’t have any effect! She, being 25 or so years younger than I am, I wonder if there’s any ageism involved here? Maybe she views it as too little, too late for an old fart like me … LOL! That just reminds me (again) that I need to start investigating online doctors to see if I can find someone else who is a bit more enlightened on this topic! I’d like to get that prescription.
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Thank you for the update. If you decide to use melatonin again, l would be interested in your dosage and thought process.
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Where are you located? If in the US, you should be able to get vaccinated at any of your chain pharmacies, or the pharmacy where you usually get your prescriptions filled. At least that’s what I do. I don’t waste time trying to convince my PCP that a vaccine is not going to kill me, not going to get me high, not going to personally hurt him, not going to demolish his office or collapse the hospital building and on and on and on. I don’t involve him at all. Here’s how:
I go to CVS.com, select the vaccine, make the online appointment time, select my CVS branch and confirm.
The date of the appointment arrives, I get an email from a cvs.com bot half an hour before I’m scheduled telling me that there was a problem with my appointment and it has been cancelled and I should make a new appointment (which will be cancelled again and now you are in an endless loop with an unresponsive and cryptic bot).
Instead, I ignore the email and turn up at the pharmacy at the originally appointed time. The pharmacist informs me that they can’t help me, because my insurance will not pay for the vaccine, so there is nothing they can do, and that is why the bot sent the email with the cancellation. I listen politely, nod with understanding, and pull out my credit card saying: “that’s fine, I’ll pay out of pocket”. The pharmacist with disbelief, checks again “but that’s $478!”. I smile apologetically “oh, well, some people you couldn’t pay to get a vaccine, I’m one of those who will pay to get a vaccine!”. The pharmacist is now irate that he has to go through the hassle of vaccinating someone, and coldly charges my cc and makes me sign, without looking at me. I look at the $478, and add up all the other vaccines I’ve recently paid for and it’s a tidy sum, and I think how all of this is pure speculation and probably useless and I’m an utter fool for doing this nonsense with no proof and I grow depressed and weak in the knees, but the chair is ready for me to sit on and I collapse waiting for the shot.
The pharmacist swabs my arm, administers the shot. I timidly ask which exact brand and dosage was used. I need this info, because depending on the exact shot, I may or may not need a booster and there are different schedules and so on. The pharmacist is now even more irate, and quickly rattles off the info, which I make sure to register and remember, because you don’t always get that info in your account.
I thank him, amble off and consider my next useless steps and plot more vaccines to get stabbed with, all to no purpose as we’re all gonna die anyway.
Anyhow, that’s my MO, you are welcome to improve on it. YMMV.
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