The above comments by @RobTuck and @McAlister are certainly welcome here by me since I am new to this forum. Different viewpoints are good, Keep it coming!
my top 5
Drugs:
1- rapamycin
2- jardiance SGLT2
3-tadafalil
4-low dose naltrexone
5- selegiline
Supplement:
1- omega 3
2- vit D/ K
3-natto
4-cocoa powder
5-PHGG
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Since my selegiline source dried up, I’m looking to find another. Any suggestions, please?
Selegiline is a generic and a relatively inexpensive medication. I may be prescribed by any doctor with a medical licence.
Could you, please, tell me why are you taking this medication and what is the dose?
I would like to take it prophylactically for mental acuity. I don’t know that my doctor would prescribe it, so I’ve tried to get it elsewhere.
Might you have a suggestion?
Here is the research on Selegeline:
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My top list now:
- Rapamycin
- SGLT2i (or acarbose)
- Statin (or other LDL lowering)
- Glycine
- Selegiline
Bonus for males: finasteride. I’d probably replace glycine with fin for males if restricted to 5.
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For how long have you been using it? Which dose? What are the effects so far? And what’s your reasoning to use it? (I’m just curious) @Paul: what about you?
Only for a week so far consistently, at 1.25mg and don’t notice any effects. Reasoning is mainly lifespan increases in animals and Paul Kiesow’s impressive n=1 .
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Been using it for about a year now 1.25mg daily under my tongue, no side effects and a lift in mood very mellow but noticeable (mainly noticeable if I stop it for a week or so and then I can tell the difference). I took modafinil few times and it has a significant mood lifting effect but unlike selegiline I wouldn’t do it long term. It’s hard to explain (other than the crash when it wanes off) but it’s one of those things that your body tells you it’s not good (if it makes sense) Get same feeling with alcohol my body tells me it’s no good despite the initial rush of good/socializing mood, with Moda I feel almost same as with alcohol. Whereas with Selegiline is the opposite, if I forget to take it my body asks for it but in a good non addictive way.
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Thanks.
What I find weird with selegiline is that the Hungarian and Japanese teams that claimed its life-extension properties… gave up! They stopped publishing articles about it. They even shifted to other compounds and a selegiline derivative. Surely, if you discover a wonderful thing that extends lifespan, you keep studying it? (And at least you take it yourself daily?)
Then, regarding Paul Kiesow, he’s a very nice guy (we chatted a bit) but:
- He did not use selegiline for years; he only recently restarted it (2023), so it’s hard to attribute his performance to that only: “Actually, selegiline since 1996 (then known as L-deprenyl) with a several-year hiatus when I could not buy it.” and “a nine-year hiatus” But in recent posts, he only says he’s been using it since 1996 without mentioning the 9-y pause. This is dishonest.
- He does many other things to stay in shape + takes other things: high-dose NMN, resveratrol, metformin, caffeine, melatonin, UDCA, etc.
- He patented his protocol (“Æther Stasis”) recently, and I assume he intends to sell it, so he now has financial incentives that might bias him.
- (Also, I know people his age who look as good and do nothing, could be genetics)
What we can say based on his example is that long-term daily low-dose selegiline does not cause much harm. But it’s hard to say much more…
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Thanks. Do you mean 1.25 mg approved Zelapar/ODT? Or that you’re taking the normal 5 mg pill (supposed to be taken orally) and split it in 4 and put that under your tongue?
Well, its all relative though. since 1996 that’s 30 year window and even if he had a 9 years pause it still leaves 21 years of usage, and that is plenty so might as well claim the whole 30. So, I’m not willing to punish his honesty for that LOl.
I bought selgin 5mg (generic form) from India and split it in 4. I don’t know if this version is supposed to be taken under the tongue, but I do it anyway.
If you took it for 20y you say… 20y 
It’s not supposed to be taken under the tongue. Under the tongue MAO-B inhibition is stronger while l-methamphetamine/l-amphetamine metabolites may be stronger. I don’t know if it’s good or bad but it’s not how it was designed. There’s a specific sublingual version called Zelapar/Zydis.
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…and please tell me your source. I’m having a hard time finding it (Selegiline).
what dosage of glycine, please? And likely on an empty stomach…
1.25 mg daily - seems like a good protocol to maintain brain function
Based on which papers?